Duan Qi-Jia, Zhao Zhong-Yi, Zhang Yao-Jun, Fu Liangbing, Yuan You-Yong, Du Jin-Zhi, Wang Jun
School of Medicine, South China University of Technology, Guangzhou 510006, China.
School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Adv Drug Deliv Rev. 2023 May;196:114793. doi: 10.1016/j.addr.2023.114793. Epub 2023 Mar 22.
Surgery and drug therapy are the two principal options for cancer treatment. However, their clinical benefits are hindered by the difficulty of accurate location of the tumors and timely monitoring of the treatment efficacy of drugs, respectively. Rapid development of imaging techniques provides promising tools to address these challenges. Compared with conventional imaging techniques such as magnetic resonance imaging and computed tomography etc., fluorescence imaging exhibits high spatial resolution, real-time imaging capability, and relatively low costs devices. The advancements in fluorescent probes further accelerate the implementation of fluorescence imaging in tumor diagnosis and treatment monitoring. In particular, the emergence of site-specifically activatable fluorescent probes fits the demands of tumor delineation and real-time feedback of the treatment efficacy. A variety of small molecule probes or nanoparticle-based probes have been developed and explored for the above-mentioned applications. This review will discuss recent advances in fluorescent probes with a special focus on activatable nanoprobes and highlight the potential implementation of activatable nanoprobes in fluorescence imaging-guided surgery as well as imaging-guided drug therapy.
手术和药物治疗是癌症治疗的两种主要选择。然而，它们的临床益处分别受到肿瘤准确定位困难和药物治疗疗效及时监测的阻碍。成像技术的快速发展为应对这些挑战提供了有前景的工具。与磁共振成像和计算机断层扫描等传统成像技术相比，荧光成像具有高空间分辨率、实时成像能力以及相对低成本的设备。荧光探针的进步进一步加速了荧光成像在肿瘤诊断和治疗监测中的应用。特别是，位点特异性可激活荧光探针的出现符合肿瘤描绘和治疗疗效实时反馈的需求。已经开发并探索了多种小分子探针或基于纳米颗粒的探针用于上述应用。本综述将讨论荧光探针的最新进展，特别关注可激活纳米探针，并强调可激活纳米探针在荧光成像引导手术以及成像引导药物治疗中的潜在应用。
