de Catanzaro D
Department of Psychology, McMaster University, Hamilton, Canada.
Neuroendocrinology. 1987 Dec;46(6):468-74. doi: 10.1159/000124867.
Corticosterone was administered through various modes into several brain regions of estrogen-treated adrenalectomized-ovariectomized female rats. Daily administration of 20 micrograms corticosterone dissolved in propylene glycol through intracerebral cannulae effectively inhibited female sexual receptivity at each of four sites: third ventricle, ventro-medial hypothalamus, preoptic area, and septum. Similar administration of lesser daily doses failed to inhibit receptivity. Implantation of pure crystalline corticosterone also had no effect on receptivity at any site. Beeswax pellets chronically releasing low doses of corticosterone significantly inhibited receptivity when implanted in the medial hypothalamus and preoptic area, with similar nonsignificant trends in the lateral septum and medial forebrain bundle, but had no effect in the dorsal hippocampus or the amygdala. The effective sites are similar to those in which estrogen activity is known to induce receptivity and those in which serotonergic activity is believed to inhibit receptivity, but do not entirely correspond to sites in the brain showing the greatest uptake of corticosterone.
将皮质酮通过多种方式注射到经雌激素处理的肾上腺切除和卵巢切除的雌性大鼠的几个脑区。通过脑内套管每日注射溶解于丙二醇中的20微克皮质酮，可有效抑制四个部位的雌性性接受能力，这四个部位分别是第三脑室、下丘脑腹内侧核、视前区和隔区。每日注射较小剂量则无法抑制性接受能力。植入纯结晶皮质酮对任何部位的性接受能力也均无影响。长期释放低剂量皮质酮的蜂蜡丸植入下丘脑内侧和视前区时，可显著抑制性接受能力，外侧隔区和内侧前脑束也有类似的非显著趋势，但对背侧海马体或杏仁核没有影响。这些有效部位与已知雌激素活性可诱导性接受能力的部位以及据信5-羟色胺能活性可抑制性接受能力的部位相似，但并不完全对应于大脑中皮质酮摄取量最大的部位。
