de Catanzaro D, Knipping R P, Wigmore S W
Pharmacol Biochem Behav. 1983 Apr;18(4):535-9. doi: 10.1016/0091-3057(83)90277-0.
Previously it has been established that adrenalectomy facilitates lordosis in estrogen-primed ovariectomized female rats and that corticosterone administration restores lordosis to preadrenalectomy levels. The present study examined the effects of an inhibitor of the synthesis of corticosterone, metyrapone, upon lordosis in ovariectomized females. In Experiment 1, chronic administration of moderate doses of metyrapone was found to facilitate lordosis. In Experiment 2, a single metyrapone administration at various doses and time intervals before testing had a mild facilitatory effect on lordosis. Experiment 3 compared the effects of metyrapone on ovariectomized and adrenalectomized-ovariectomized females. The absence of a facilitatory effect in adrenalectomized females suggests that the drug's effect on lordosis is mediated by its established inhibitory effects on 11 beta-hydroxylation in the adrenal. These data are consistent with indications that corticosterone titer modulates female receptivity.
先前已经确定，肾上腺切除术可促进经雌激素预处理的去卵巢雌性大鼠的脊柱前凸，而给予皮质酮可使脊柱前凸恢复到肾上腺切除术前的水平。本研究考察了皮质酮合成抑制剂美替拉酮对去卵巢雌性大鼠脊柱前凸的影响。在实验1中，发现长期给予中等剂量的美替拉酮可促进脊柱前凸。在实验2中，在测试前不同剂量和时间间隔单次给予美替拉酮对脊柱前凸有轻微的促进作用。实验3比较了美替拉酮对去卵巢和肾上腺切除-去卵巢雌性大鼠的影响。去肾上腺雌性大鼠中没有促进作用，这表明该药物对脊柱前凸的作用是通过其对肾上腺11β-羟化作用已确定的抑制作用介导的。这些数据与皮质酮水平调节雌性大鼠接受性的指征一致。
