deCatanzaro D, Knipping R P, Gorzalka B B
Pharmacol Biochem Behav. 1981 Nov;15(5):761-6. doi: 10.1016/0091-3057(81)90019-8.
Previous experimentation has established that adrenalectomy can facilitate lordosis in ovariectomized estrogen-primed female rats. Experiment 1 examined the role of adrenal steroids in this effect, the results indicating an attenuation with chronic corticosterone but not with desoxycorticosterone or progesterone administration. Experiment 2 established a dose-response curve for this corticosterone effect. Experiments 3 and 4 indicated that corticosterone administration inhibits lordosis when it precedes estrogen administration. Experiment 5 demonstrated that corticosterone also inhibits estrogen-induced lordosis in mice. These data suggest that corticosterone may modulate estrogen-mediated behavior in rodents.
先前的实验已证实，肾上腺切除术可促进卵巢切除且经雌激素预处理的雌性大鼠出现脊柱前凸。实验1研究了肾上腺类固醇在这一效应中的作用，结果表明，长期给予皮质酮会减弱该效应，但给予脱氧皮质酮或孕酮则不会。实验2确定了这种皮质酮效应的剂量反应曲线。实验3和4表明，在给予雌激素之前给予皮质酮会抑制脊柱前凸。实验5证明，皮质酮也会抑制小鼠中雌激素诱导的脊柱前凸。这些数据表明，皮质酮可能会调节啮齿动物中雌激素介导的行为。
