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涂层治疗破裂动脉瘤的长期结果。

Long term results of ruptured aneurysms treated by coating.

作者信息

Minakawa T, Koike T, Fujii Y, Ishii R, Tanaka R, Arai H

机构信息

Department of Neurosurgery, Niigata University, Japan.

出版信息

Neurosurgery. 1987 Nov;21(5):660-3. doi: 10.1227/00006123-198711000-00010.

Abstract

We report the long term results of the treatment of 23 intracranial ruptured aneurysms by coating. Twenty-three patients treated by coating were followed for a mean period of 11.2 years. The mean interval between the last hemorrhage and the operation was 22.4 days. Ten aneurysms underwent total coating, 9 with Biobond and 1 with Aron Alpha. Thirteen aneurysms underwent partial coating, 11 with Biobond and 2 with Aron Alpha. Six aneurysms were reinforced partially by other materials, but no aneurysm was wrapped totally with these materials. Rebleeding occurred in 6 patients, of whom 5 died. The mean interval between coating and rebleeding was 4 years. All patients suffering rebleeding had been treated with Biobond, and 3 patients had undergone total coating of aneurysms. The risk of recurrent hemorrhage after total coating with Biobond was 33%. One rebleeding patient underwent a second operation 10.5 years after total coating of the aneurysm. Biobond was found only at the tip of the aneurysmal sac. From these results, reinforcement of ruptured aneurysms with Biobond seems to be of little value, and a more reliable method must be developed for aneurysms that cannot be clipped.

摘要

我们报告了23例颅内破裂动脉瘤涂层治疗的长期结果。对23例接受涂层治疗的患者进行了平均11.2年的随访。末次出血与手术之间的平均间隔为22.4天。10例动脉瘤进行了完全涂层,9例使用生物粘合剂(Biobond),1例使用阿隆阿尔法(Aron Alpha)。13例动脉瘤进行了部分涂层,11例使用生物粘合剂,2例使用阿隆阿尔法。6例动脉瘤用其他材料进行了部分加固,但没有动脉瘤用这些材料完全包裹。6例患者发生再出血,其中5例死亡。涂层与再出血之间的平均间隔为4年。所有发生再出血的患者均接受了生物粘合剂治疗,3例患者的动脉瘤进行了完全涂层。生物粘合剂完全涂层后复发出血的风险为33%。1例再出血患者在动脉瘤完全涂层10.5年后接受了二次手术。仅在动脉瘤囊的尖端发现了生物粘合剂。从这些结果来看,用生物粘合剂加固破裂动脉瘤似乎价值不大,对于无法夹闭的动脉瘤必须开发出更可靠的方法。

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