Koshu K, Hirota S, Sonobe M, Takahashi S, Takaku A, Saito T, Ushijima T
Department of Neurosurgy, Mito National Hospital, Japan.
Neurosurgery. 1987 Nov;21(5):693-8. doi: 10.1227/00006123-198711000-00016.
The thermal diffusion method is known to be effective for making quantitative measurements of blood flow, but cannot be easily applied to problems concerning quantitative changes in blood flow. Carter et al. found that the thermal diffusion technique using a Peltier stack as the probe produced extremely stable recordings and was suitable for quantitative work. We made a more stable probe containing an air space and having a stainless cap that added weight. A stable recording of blood flow was then possible. For calibration of the probe, we used blood flow values measured by means of an electrolytic technique and the equation proposed by Carter et al. In the present study, we have shown that it is theoretically possible to perform the calibration even without obtaining data on blood flow after cardiac arrest. Experimentally, the validity of such calibration was confirmed. This technique for measuring blood flow should be applicable in various fields and its use in a clinical setting, particularly in the monitoring of blood flow during neurosurgical operations, can be expected.
热扩散法已知对血流量进行定量测量有效，但不易应用于有关血流量定量变化的问题。卡特等人发现，使用珀耳帖堆作为探头的热扩散技术能产生极其稳定的记录，适用于定量工作。我们制作了一个更稳定的探头，它含有一个气隙并有一个加重的不锈钢帽。这样就有可能获得稳定的血流量记录。为了校准探头，我们使用了通过电解技术测量的血流量值以及卡特等人提出的方程。在本研究中，我们已表明，即使在心脏骤停后未获取血流量数据的情况下，理论上也有可能进行校准。通过实验，证实了这种校准的有效性。这种测量血流量的技术应可应用于各个领域，并且有望在临床环境中使用，特别是在神经外科手术期间监测血流量。
