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烧伤后收缩的二维生物弹塑性模型的稳定性。

Stability of a two-dimensional biomorphoelastic model for post-burn contraction.

机构信息

Delft Institute of Applied Mathematics, Delft University of Technology, Delft, The Netherlands.

Research Group Computational Mathematics (CMAT), Department of Mathematics and Statistics, University of Hasselt, Hasselt, Belgium.

出版信息

J Math Biol. 2023 Mar 24;86(4):59. doi: 10.1007/s00285-023-01893-w.

DOI:10.1007/s00285-023-01893-w
PMID:36964257
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10038978/
Abstract

We consider the stability analysis of a two-dimensional model for post-burn contraction. The model is based on morphoelasticity for permanent deformations and combined with a chemical-biological model that incorporates cellular densities, collagen density, and the concentration of chemoattractants. We formulate stability conditions depending on the decay rate of signaling molecules for both the continuous partial differential equations-based problem and the (semi-)discrete representation. We analyze the difference and convergence between the resulting spatial eigenvalues from the continuous and semi-discrete problems.

摘要

我们研究了一种用于烧伤后收缩的二维模型的稳定性分析。该模型基于永久性变形的形态弹性力学,并结合了一个包含细胞密度、胶原蛋白密度和趋化因子浓度的化学生物学模型。我们根据信号分子的衰减率为基于连续偏微分方程的问题和(半)离散表示制定了稳定性条件。我们分析了连续和离散问题得出的空间特征值之间的差异和收敛性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/602beb100ee8/285_2023_1893_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/5183b0e88355/285_2023_1893_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/090579250230/285_2023_1893_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/adc1e98dc0bb/285_2023_1893_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/bb4eea03610e/285_2023_1893_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/a7d026a99cea/285_2023_1893_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/9dfa4d926640/285_2023_1893_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/7e4ab8372ebf/285_2023_1893_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/602beb100ee8/285_2023_1893_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/5183b0e88355/285_2023_1893_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/090579250230/285_2023_1893_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/adc1e98dc0bb/285_2023_1893_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/bb4eea03610e/285_2023_1893_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/a7d026a99cea/285_2023_1893_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/9dfa4d926640/285_2023_1893_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/7e4ab8372ebf/285_2023_1893_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a5a/10038978/602beb100ee8/285_2023_1893_Fig8_HTML.jpg

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Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation.针对 TGF-β/Smad 信号通路的当前潜在治疗策略,以减轻瘢痕疙瘩和增生性瘢痕的形成。
Biomed Pharmacother. 2020 Sep;129:110287. doi: 10.1016/j.biopha.2020.110287. Epub 2020 Jun 12.
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A Critical Update of the Assessment and Acute Management of Patients with Severe Burns.
严重烧伤患者评估与急性处理的重要更新
Adv Wound Care (New Rochelle). 2019 Dec 1;8(12):607-633. doi: 10.1089/wound.2019.0963. Epub 2019 Nov 6.
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Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring.烧伤:烧伤创面愈合、感染、疼痛和瘢痕形成的挑战与进展。
Adv Drug Deliv Rev. 2018 Jan 1;123:3-17. doi: 10.1016/j.addr.2017.09.018. Epub 2017 Sep 20.
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A model for one-dimensional morphoelasticity and its application to fibroblast-populated collagen lattices.一维形态弹性模型及其在成纤维细胞填充胶原水凝胶中的应用。
Biomech Model Mechanobiol. 2017 Oct;16(5):1743-1763. doi: 10.1007/s10237-017-0917-3. Epub 2017 May 18.
6
Biomedical implications from a morphoelastic continuum model for the simulation of contracture formation in skin grafts that cover excised burns.一种用于模拟覆盖切除烧伤创面的皮肤移植中挛缩形成的形态弹性连续介质模型的生物医学意义。
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A mathematical model for the simulation of the formation and the subsequent regression of hypertrophic scar tissue after dermal wounding.一种用于模拟皮肤创伤后增生性瘢痕组织形成及后续消退的数学模型。
Biomech Model Mechanobiol. 2017 Feb;16(1):15-32. doi: 10.1007/s10237-016-0799-9. Epub 2016 May 26.
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Numerical modelling of the angiogenesis process in wound contraction.数值模拟伤口收缩过程中的血管生成。
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A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics.一种包含真实生长因子动力学的皮肤伤口闭合的纤维收缩机械化学模型。
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