从秒到天：通过脂质透镜观察神经可塑性。

From seconds to days: Neural plasticity viewed through a lipid lens.

机构信息

Department of Neurobiology, Stanford University, Stanford, CA, 94305, United States; Department of Developmental Biology, Stanford University, Stanford, CA, 94305, United States. Electronic address: https://twitter.com/gliaful.

Department of Neurobiology, Stanford University, Stanford, CA, 94305, United States. Electronic address: https://twitter.com/emmaktheisen.

出版信息

Curr Opin Neurobiol. 2023 Jun;80:102702. doi: 10.1016/j.conb.2023.102702. Epub 2023 Mar 23.

DOI:10.1016/j.conb.2023.102702

PMID:36965206

Abstract

Many adult neurons are dynamically remodeled across timescales ranging from the rapid addition and removal of specific synaptic connections, to largescale structural plasticity events that reconfigure circuits over hours, days, and months. Membrane lipids, including brain-enriched sphingolipids, play crucial roles in these processes. In this review, we summarize progress at the intersection of neuronal activity, lipids, and structural remodeling. We highlight how brain activity modulates lipid metabolism to enable adaptive structural plasticity, and showcase glia as key players in membrane remodeling. These studies reveal that lipids act as critical signaling molecules that instruct the dynamic architecture of the brain.

摘要

许多成年神经元在不同时间尺度上进行动态重塑，从快速增加和去除特定的突触连接，到在数小时、数天和数月内重新配置电路的大规模结构可塑性事件。膜脂质，包括富含脑的神经酰胺，在这些过程中发挥着关键作用。在这篇综述中，我们总结了神经元活动、脂质和结构重塑交叉点的进展。我们强调了大脑活动如何调节脂质代谢以实现适应性结构可塑性，并展示了胶质细胞作为膜重塑的关键参与者。这些研究表明，脂质作为关键的信号分子，指导大脑的动态结构。