College of pharmacy, Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan 250355, China.
College of pharmacy, Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan 250355, China.
Int J Biol Macromol. 2023 May 15;237:124146. doi: 10.1016/j.ijbiomac.2023.124146. Epub 2023 Mar 23.
Bupleuri Radix (BR), as a well-known plant medicine of relieving exterior syndrome, has a long history of usage in China. Bupleuri Radix Polysaccharide (BRP), as the main component and an important bioactive substance of BR, has a variety of pharmacological activities, including immunoregulation, antioxidant, antitumor, anti-diabetic and anti-aging, etc. In this review, the advancements on extraction, purification, structure characteristics, biological activities and pharmaceutical application of BRP from different sources (Bupleurum chinense DC., Bupleurum scorzonerifolium Willd., Bupleurum falcatum L. and Bupleurum smithii Woiff. var. Parvifolium Shan et Y. Li.) are summarized. Meanwhile, this review makes an in-depth discussion on the shortcomings of the research on BRP, and new valuable insights for the future researches of BRP are proposed.
柴胡（BR）作为一种著名的解表植物药，在中国已有悠久的应用历史。柴胡多糖（BRP）作为 BR 的主要成分和重要生物活性物质，具有多种药理活性，包括免疫调节、抗氧化、抗肿瘤、抗糖尿病和抗衰老等。本文综述了不同来源（北柴胡、狭叶柴胡、华柴胡和三岛柴胡）的 BRP 的提取、纯化、结构特征、生物活性和药用应用方面的最新进展。同时，本文还深入讨论了 BRP 研究的不足之处，并为 BRP 的未来研究提出了新的有价值的见解。
