Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Biochim Biophys Acta Rev Cancer. 2023 May;1878(3):188881. doi: 10.1016/j.bbcan.2023.188881. Epub 2023 Mar 23.
A carrier is inserted into the appropriate organelles (nucleus) in successful medication transport, crucial to achieving very effective illness treatment. Cell-membrane targeting is the major focus of using nuclei to localize delivery. It has been demonstrated that high quantities of anticancer drugs can be injected directly into the nuclei of cancer cells, causing the cancer cells to die and increasing the effectiveness of chemotherapy. There are several effective ways to functionalize Nanoparticles (NPs), including changing their chemical makeup or attaching functional groups to their surface to increase their ability to target organelles. To cause tumor cells to apoptosis, released medicines must engage with molecular targets on particular organelles when their concentration is high enough. Targeted medication delivery studies will increasingly focus on organelle-specific delivery.
载体被插入到成功的药物输送的适当细胞器（核）中，这对实现非常有效的疾病治疗至关重要。细胞膜靶向是利用核定位传递的主要焦点。已经证明，大量的抗癌药物可以直接注射到癌细胞的核中，导致癌细胞死亡，并提高化疗的效果。有几种有效的方法可以使纳米粒子（NPs）功能化，包括改变它们的化学成分或在其表面附着功能基团，以提高它们靶向细胞器的能力。为了使肿瘤细胞凋亡，当药物浓度足够高时，释放的药物必须与特定细胞器上的分子靶标结合。靶向药物输送研究将越来越关注细胞器特异性输送。
