Yang Yannan, Yu Chengzhong
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD, Australia.
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD, Australia.
Nanomedicine. 2016 Feb;12(2):317-32. doi: 10.1016/j.nano.2015.10.018. Epub 2015 Dec 17.
Targeted delivery of anticancer drug specifically to tumor site without damaging normal tissues has been the dream of all scientists fighting against cancer for decades. Recent breakthrough on nanotechnology based medicines has provided a possible tool to solve this puzzle. Among diverse nanomaterials that are under development and extensive study, silica based nanoparticles with vast advantages have attracted great attention. In this review, we concentrate on the recent progress using silica based nanoparticles, particularly mesoporous silica nanoparticles (MSNs), for targeted drug delivery applications. First, we discuss the passive targeting capability of silica based nanoparticles in relation to their physiochemical properties. Then, we focus on the recent advances of active targeting strategies involving tumor cell targeting, vascular targeting, nuclear targeting and multistage targeting, followed by an introduction to magnetic field directed targeting approach. We conclude with our personal perspectives on the remaining challenges and the possible future directions.
Chemotherapy has been one of the mainstays of cancer treatment. The advances in nanotechnology has allowed the development of novel carrier systems for the delivery of anticancer drugs. Mesoporous silica has shown great promise in this respect. In this review article, the authors provided a comprehensive overview of the use of this nanoparticle in both passive, as well as active targeting in the field of oncology. The advantages of this particle were further discussed.
几十年来，将抗癌药物特异性地靶向递送至肿瘤部位而不损害正常组织一直是所有抗癌科学家的梦想。基于纳米技术的药物的最新突破为解决这一难题提供了一种可能的工具。在正在开发和广泛研究的各种纳米材料中，具有巨大优势的二氧化硅基纳米颗粒引起了极大关注。在这篇综述中，我们专注于使用二氧化硅基纳米颗粒，特别是介孔二氧化硅纳米颗粒（MSN）进行靶向药物递送应用的最新进展。首先，我们讨论二氧化硅基纳米颗粒的被动靶向能力与其物理化学性质的关系。然后，我们重点关注涉及肿瘤细胞靶向、血管靶向、核靶向和多级靶向的主动靶向策略的最新进展，接着介绍磁场导向靶向方法。我们以对剩余挑战和可能的未来方向的个人观点作为总结。
化疗一直是癌症治疗的主要手段之一。纳米技术的进步使得开发用于递送抗癌药物的新型载体系统成为可能。介孔二氧化硅在这方面已显示出巨大的前景。在这篇综述文章中，作者全面概述了这种纳米颗粒在肿瘤学领域的被动靶向和主动靶向中的应用。进一步讨论了这种颗粒的优势。
