Institute of Photomedicine Shanghai Skin Disease Hospital School of Medicine, Tongji University, Shanghai 200443, China; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China.
Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China; Department of Pathology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China.
Photodiagnosis Photodyn Ther. 2023 Jun;42:103524. doi: 10.1016/j.pdpdt.2023.103524. Epub 2023 Mar 23.
Malignant proliferating trichilemmal tumor (MPTT) is thought to represent the malignant counterpart of benign proliferative pilar cyst, a lesion originating from the outer hair root sheath. We report a case of an 86-year-old woman with an exophytic nodule containing an ulcerated surface in the temporal region. Histopathologically confirmed MPTT without metastasis, and considering the risk of metastasis and recurrence, we used single local narrow margin excision combined with modified 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT). No recurrence of skin lesions was found in the 2-year follow-up after combined therapy. In conclusion, local narrow margin excision sequential with modified ALA-PDT may be a particularly promising and effective treatment option for MPTT.
恶性增殖性毛母细胞瘤（MPTT）被认为是良性增殖性毛鞘囊肿的恶性对应物，后者起源于外毛根鞘。我们报告了一例 86 岁女性患者，颞部有一个外生结节，表面有溃疡。组织病理学证实为 MPTT 且无转移，考虑到转移和复发的风险，我们采用了单一局部窄缘切除联合改良 5-氨基酮戊酸介导的光动力疗法（ALA-PDT）。联合治疗后 2 年随访未发现皮肤病变复发。总之，局部窄缘切除序贯改良 ALA-PDT 可能是 MPTT 一种特别有前途和有效的治疗选择。
