Larsson L I, Rehfeld J F
Brain Res. 1979 Apr 13;165(2):201-18. doi: 10.1016/0006-8993(79)90554-7.
Immunocytochemistry and radioimmunochemistry demonstrate the occurrence of the gastrointestinal hormone cholecystokinin (CCK) in both the central and peripheral nervous system of the guinea pig. CCK nerves are particularly numerous in the neocortex, the hippocampus, the amygdaloid nuclei, the hypothalamus, the spinal cord and in the colon. The nerves contain 5 molecular components of CCK, with gel chromatographical elution constants (Kav) of 0.05, 0.50, 0.90, 1.10 and 1.30, respectively. The four latter correspond to triacontatriapeptide CCK and its COOH-terminal dodeca-, octa- and tetrapeptide portions, respectively. Cholecystokinins are hence widely distributed in the nervous system and occur in the substantial quantities (greater than or equal to 0.2 nmol CCK-8-equiv./g) in several distinct regions.
免疫细胞化学和放射免疫化学证明，豚鼠的中枢神经系统和外周神经系统中均存在胃肠激素胆囊收缩素（CCK）。CCK神经在新皮质、海马体、杏仁核、下丘脑、脊髓和结肠中特别多。这些神经含有CCK的5种分子成分，其凝胶色谱洗脱常数（Kav）分别为0.05、0.50、0.90、1.10和1.30。后四种成分分别对应于三十三联肽CCK及其COOH末端的十二肽、八肽和四肽部分。因此，胆囊收缩素广泛分布于神经系统中，并且在几个不同区域中大量存在（大于或等于0.2 nmol CCK-8等效物/克）。
