Environmental Epigenomics Lab, Department of Environmental Science, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, West Bengal, 700019, India.
Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, West Bengal, 700019, India.
Sci Rep. 2023 Mar 25;13(1):4895. doi: 10.1038/s41598-023-31977-y.
Ectopic fat deposition is more strongly associated with obesity-related health problems including type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), hypothyroidism, arthritis, etc. Our study aimed at identifying the cumulative role of several risk factors in developing obesity and the role of ectopic fat (visceral fat) in predicting cardiovascular disease risk in varied age groups among urban adult academic professionals in West Bengal. 650 adults (Male = 456; Female = 194) associated with the academic job (age 20-65 years) in urban West Bengal were randomly selected for anthropometric, blood biochemical, and questionnaire-based analyses. Body Mass Index and Visceral Fat% exhibited comparable association with all the other anthropometric parameters (e.g. Whole body Subcutaneous fat%: male-Linear Regression Comparison: F = 11.68; P < 0.001; female-F = 6.11; P < 0.01). Therefore, VF% acts as a risk factor alongside BMI in instances where BMI fails alone. The presence of T2DM, hypertension, and hypothyroidism in the case groups confirmed their obesity-associated longitudinal pattern of inheritance. Unhealthy diet pattern indicates improper liver function, vitamin D deficiency, and increased erythrocytic inflammation. An overall sedentary lifestyle with parental history of obesity was found to be significant in the longitudinal transmission of the disease.
异位脂肪沉积与肥胖相关的健康问题（包括 2 型糖尿病、心血管疾病、甲状腺功能减退症、关节炎等）的相关性更强。我们的研究旨在确定几种风险因素在肥胖发展中的累积作用，以及异位脂肪（内脏脂肪）在预测不同年龄段城市成年学术专业人员心血管疾病风险中的作用。我们在西孟加拉邦的城市中随机选择了 650 名与学术工作相关的成年人（男性=456 名；女性=194 名）进行了人体测量、血液生化和问卷调查分析。身体质量指数和内脏脂肪%与所有其他人体测量参数具有相似的关联（例如，全身皮下脂肪%：男性-线性回归比较：F=11.68；P<0.001；女性-F=6.11；P<0.01）。因此，在 BMI 单独作用不足的情况下，VF% 作为一种风险因素与 BMI 一起发挥作用。病例组中存在 2 型糖尿病、高血压和甲状腺功能减退症，证实了它们与肥胖相关的遗传纵向模式。不健康的饮食模式表明肝功能异常、维生素 D 缺乏和红细胞炎症增加。发现整体久坐的生活方式和肥胖的父母史在疾病的纵向传播中具有重要意义。
