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[耐大环内酯类肺炎支原体:我们了解欧洲的情况吗?]

[Macrolide-resistant Mycoplasma pneumoniae: Do we know the situation in Europe?].

作者信息

Álvaro Varela A I, Aguinaga Pérez A, Navascués Ortega A, Castilla Catalán J, Ezpeleta Baquedano C

机构信息

Ana Isabel Álvaro Varela, Servicio de Microbiología Clínica, Hospital Universitario de Navarra, Pamplona, Spain.

出版信息

Rev Esp Quimioter. 2023 Jun;36(3):259-266. doi: 10.37201/req/118.2022. Epub 2023 Mar 27.

Abstract

Mycoplasma pneumoniae is a bacterium that lacks a cell wall. It produces infections all It produces infections world-wide, in epidemic outbreaks every 4-7 years, or endemically. Its clinical manifestations occur mostly in the respiratory tract and it is a common cause of atypical pneumonia. The treatment is with macrolides, tetracyclines or fluoroquinolones. Since 2000, an increase in resistance to macrolides has been detected worldwide, being more frequent in Asia. In Europe the frequency of resistance ranges between 1% and 25%, depending on the country. Molecular techniques and serology techniques provides very high sensitivity in diagnostic confirmation, being very useful for detecting and controlling M. pneumoniae outbreaks. The detection of resistance to macrolides requires a sequencing technique.

摘要

肺炎支原体是一种没有细胞壁的细菌。它在全球范围内引发感染,每4至7年出现一次流行暴发,或呈地方性流行。其临床表现主要出现在呼吸道,是不典型肺炎的常见病因。治疗药物为大环内酯类、四环素类或氟喹诺酮类。自2000年以来,全球范围内已检测到对大环内酯类药物的耐药性增加,在亚洲更为常见。在欧洲,耐药频率在1%至25%之间,因国家而异。分子技术和血清学技术在诊断确认方面具有很高的灵敏度,对检测和控制肺炎支原体暴发非常有用。检测对大环内酯类药物的耐药性需要测序技术。

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1
Clinical characteristics of patients with Mycoplasma pneumoniae infection.肺炎支原体感染患者的临床特征。
Enferm Infecc Microbiol Clin (Engl Ed). 2022 Oct;40(8):449-452. doi: 10.1016/j.eimce.2022.08.002. Epub 2022 Sep 22.

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