Medical Oncology Department, Catalan Institute of Oncology-Badalona (ICO), Applied Research Group in Oncology (B-ARGO), IGTP, 08916 Badalona.
Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)-IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona.
Curr Opin Oncol. 2023 May 1;35(3):145-150. doi: 10.1097/CCO.0000000000000937. Epub 2023 Mar 20.
Human papillomavirus (HPV) is responsible of the increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in high-income countries. This significant epidemiological change requires several and diverse prevention strategies.
The cervical cancer prevention model is the paradigm of HPV-related cancer, and its success provides encouragement for the development of similar methods to prevent HPV-related OPSCC. However, there are some limitations that hinder its application in this disease. Here, we review the primary, secondary and tertiary prevention of HPV-related OPSCC and discuss some directions for future research.
The development of new and targeted strategies to prevent HPV-related OPSCC is needed since they could definitely have a direct impact on the reduction of morbidity and mortality of this disease.
人乳头瘤病毒（HPV）是导致高收入国家口咽鳞状细胞癌（OPSCC）发病率上升的罪魁祸首。这种显著的流行病学变化需要多种不同的预防策略。
宫颈癌预防模式是 HPV 相关癌症的典范，其成功为开发类似方法预防 HPV 相关 OPSCC 提供了鼓舞。然而，存在一些限制因素阻碍了其在该疾病中的应用。在这里，我们综述了 HPV 相关 OPSCC 的一级、二级和三级预防，并讨论了一些未来研究的方向。
需要开发新的、有针对性的策略来预防 HPV 相关的 OPSCC，因为它们肯定会对口咽鳞状细胞癌发病率和死亡率的降低产生直接影响。
