Tianjin Centers for Disease Control and Prevention, Tianjin, 300011, China.
Tianjin Centers for Disease Control and Prevention, Tianjin, 300011, China.
Food Chem Toxicol. 2023 Jun;176:113733. doi: 10.1016/j.fct.2023.113733. Epub 2023 Mar 24.
A 90-day rat feeding study was performed to conduct a safety assessment on L4, a multi-gene genetically modified maize, conferring "Bt" insect resistance and glyphosate tolerance. A total of 140 Wistar rats were assigned to seven groups, 10 animals/group/sex, which comprised three genetically modified groups fed diets containing different concentrations of L4, three corresponding non-genetically modified groups fed diets containing different concentrations of zheng58 (parent plants), and a basal diet group fed the standard basal diet for 13 weeks. The fed diets contained L4 and Zheng58 at w/w% percentages of 12.5%, 25.0%, and 50% of the total. Animals were evaluated on some research parameters, including general behaviour, body weight/gain, feed consumption/efficiency, ophthalmology, clinical pathology, organ weights, and histopathology. Throughout the feeding trial, all animals were in good condition. No mortality and no biologically relevant effects or toxicologically significant alterations were observed in the total research parameters of the rats in the genetically modified groups compared with those in the basal diet group or their corresponding non-genetically modified groups. No adverse effects were observed in any of the animals. The results indicated that L4 is as safe and wholesome as conventional, non-genetically modified control maize.
一项为期 90 天的大鼠喂养研究旨在对 L4 进行安全性评估，L4 是一种多基因遗传改良玉米，具有“Bt”抗虫性和草甘膦耐受性。总共将 140 只 Wistar 大鼠分配到 7 个组中，每组 10 只动物/性别，包括 3 个喂食不同浓度 L4 的遗传改良组、3 个喂食不同浓度 Zheng58（亲本植物）的相应非遗传改良组和一个喂食标准基础饮食的基础饮食组，持续 13 周。喂养的饮食中 L4 和 Zheng58 的含量分别为总重量的 12.5%、25.0%和 50%。对动物进行了一些研究参数的评估，包括一般行为、体重/增重、饲料消耗/效率、眼科、临床病理学、器官重量和组织病理学。在整个喂养试验过程中，所有动物的状况都很好。与基础饮食组或其相应的非遗传改良组相比，遗传改良组大鼠的所有研究参数均未观察到总死亡率和任何生物学相关效应或毒理学显著改变。任何动物均未观察到不良反应。结果表明，L4 与传统的非遗传改良对照玉米一样安全、健康。
