Department of Toxicology, Tianjin Centers for Disease Control and Prevention, Tianjin, 300011, China.
Department of Toxicology, Tianjin Centers for Disease Control and Prevention, Tianjin, 300011, China.
Food Chem Toxicol. 2023 Oct;180:114026. doi: 10.1016/j.fct.2023.114026. Epub 2023 Sep 12.
LP007-1 is a variety of insect-resistant and herbicide-tolerant maize containing the modified cry1Ab, cry2Ab, vip3Aa and cp4-epsps genes. The food safety assessment of the maize LP007-1 was conducted in Wistar Han RCC rats by a 90-days feeding study. Maize grains from both LP007-1 or its corresponding non-genetically modified control maize AX808 were incorporated into rodent diets at 25% and 50% concentrations by mass and administered to rats (n = 10/sex/group) for 90 days. A commercialized rodent diet was fed to an additional group as the basal-diet group. The diets of all groups were nutritionally balanced. No biologically relevant differences were observed in rats fed with maize LP007-1 compared to rats fed with AX808 and the basal-diet with respect to body weight/gain, food consumption/utilization, clinical signs, mortality, ophthalmology, clinical pathology (hematology, prothrombin time, activation of partial thrombin time, serum chemistry, urinalysis), organ weights, and gross and microscopic pathology. Considering the circumstances of this study, the results provided evidence that LP007-1 maize did not exhibit toxicity in the 90-day feeding study.
LP007-1 是一种抗虫和耐除草剂的玉米品种，含有改良的 cry1Ab、cry2Ab、vip3Aa 和 cp4-epsps 基因。通过为期 90 天的喂养研究，对玉米 LP007-1 的食品安全进行了评估。将来自 LP007-1 或其相应的非转基因对照玉米 AX808 的玉米籽粒按质量分别以 25%和 50%的浓度掺入到啮齿动物饮食中，并将其喂给大鼠（n = 10/性别/组）90 天。将商业化的啮齿动物饮食喂给另一组作为基础饮食组。所有组的饮食均具有营养均衡。与喂食 AX808 玉米和基础饮食的大鼠相比，喂食 LP007-1 玉米的大鼠在体重/增重、食物消耗/利用、临床症状、死亡率、眼科、临床病理学（血液学、凝血酶原时间、部分凝血酶时间激活、血清化学、尿液分析）、器官重量以及大体和显微镜病理学方面均未观察到具有生物学意义的差异。考虑到本研究的情况，结果表明 LP007-1 玉米在 90 天喂养研究中没有表现出毒性。
