糖尿病周围神经病变与糖尿病肾病和心血管疾病相关：西里西亚糖尿病-心脏研究。

Diabetic Peripheral Neuropathy is Associated With Diabetic Kidney Disease and Cardiovascular Disease: The Silesia Diabetes-Heart Project.

机构信息

Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland; Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, UK.

Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.

出版信息

Curr Probl Cardiol. 2023 Aug;48(8):101726. doi: 10.1016/j.cpcardiol.2023.101726. Epub 2023 Mar 24.

DOI:10.1016/j.cpcardiol.2023.101726

PMID:36967071

Abstract

Microvascular complications of diabetes seem to be clustered and put patients at higher risk of developing cardiovascular disease (CVD). This was a questionnaire-based study designed to screen for the presence of diabetic peripheral neuropathy (DPN), defined as the score in the Michigan Neuropathy Screening Instrument (MNSI) above 2, and to evaluate its association with other complication of diabetes, including CVD. There were 184 patients included into the study. The prevalence of DPN in the study group was 37.5%. The regression model analysis revealed that the presence of DPN was significantly associated with the presence of diabetic kidney disease (DKD) (P = 0.0034;) and patient's age (P < 0.0001). Thirty-four patients (49.3%) with MNSI score >2 were diagnosed with CVD in comparison to 24 (20.1%) subjects with MNSI score ≤ 2 (P = 0.00006). In case of having one diabetes complication diagnosed, it is important to screen for others, including macrovascular ones.

摘要

糖尿病的微血管并发症似乎集中出现，使患者患心血管疾病 (CVD) 的风险更高。这是一项基于问卷调查的研究，旨在筛查糖尿病周围神经病变 (DPN) 的存在，定义为密歇根神经病变筛查工具 (MNSI) 评分高于 2，并评估其与其他糖尿病并发症的关系，包括 CVD。研究共纳入 184 例患者。研究组 DPN 的患病率为 37.5%。回归模型分析显示，DPN 的存在与糖尿病肾病 (DKD) 的存在显著相关 (P=0.0034;)和患者年龄 (P<0.0001)。与 MNSI 评分≤2 的 24 名患者相比，MNSI 评分>2 的 34 名患者 (49.3%) 被诊断为 CVD (P=0.00006)。如果已经诊断出一种糖尿病并发症，重要的是要筛查其他并发症，包括大血管并发症。