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Cardiovascular Complications of Diabetes: From Microvascular to Macrovascular Pathways.

作者信息

Zakir Mehreen, Ahuja Neha, Surksha Marvi Alais, Sachdev Reya, Kalariya Yash, Nasir Muhammad, Kashif Maham, Shahzeen Fnu, Tayyab Arslan, Khan Muhammad Saood Moazzam, Junejo Mohsin, Manoj Kumar Fnu, Varrassi Giustino, Kumar Satesh, Khatri Mahima, Mohamad Tamam

机构信息

Medicine, Sir Syed College of Medical Sciences, Karachi, PAK.

General Medicine, Chandka Medical College, Larkana, PAK.

出版信息

Cureus. 2023 Sep 24;15(9):e45835. doi: 10.7759/cureus.45835. eCollection 2023 Sep.


DOI:10.7759/cureus.45835
PMID:37881393
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10594042/
Abstract

Diabetes mellitus, with a growing risk of developing complications, has a significant negative impact on cardiovascular health, including microvascular and macrovascular issues. This thorough narrative study methodically examines the complex connection between cardiovascular problems and diabetes. We start by thoroughly introducing diabetes mellitus, classifying its various forms, and discussing its growing global impact. Then, we examine retinopathy, nephropathy, and neuropathy in detail, illuminating their biology, clinical presentations, and treatment options. Moving on to macrovascular consequences, we investigate the complex relationships between diabetes and coronary artery disease, stroke, and peripheral arterial disease, emphasizing risk factors, diagnostic standards, and treatment plans designed for people with diabetes. The review analyzes the pathophysiological pathways that link diabetes to cardiovascular problems, including endothelial dysfunction, chronic inflammation, immune system dysregulation, and oxidative stress brought on by hyperglycemia. Additionally, we review the critical function of risk monitoring, assessment, and predictive tools in early detection. While highlighting current research paths and the need for tailored medical approaches to address this complex health issue, the story also includes prevention and management strategies, ranging from lifestyle changes to developing medications. This narrative review concludes by providing a thorough summary of current information, highlighting research gaps, and advocating for interdisciplinary efforts to reduce the cardiovascular effects of diabetes.

摘要

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本文引用的文献

[1]
Exploring the Complex Connection Between Diabetes and Cardiovascular Disease: Analyzing Approaches to Mitigate Cardiovascular Risk in Patients With Diabetes.

Cureus. 2023-8-21

[2]
Individualizing Medicinal Therapy Post Heart Stent Implantation: Tailoring for Patient Factors.

Cureus. 2023-8-23

[3]
Advances in the Management of Diabetes Mellitus: A Focus on Personalized Medicine.

Cureus. 2023-8-18

[4]
Deciphering the Dilemma: Anticoagulation for Heart Failure With Preserved Ejection Fraction (HFpEF).

Cureus. 2023-8-10

[5]
A Systematic Review and Meta-Analysis on the Efficacy and Safety of Finerenone Therapy in Patients with Cardiovascular and Chronic Kidney Diseases in Type 2 Diabetes Mellitus.

Cureus. 2023-7-11

[6]
Comparative Efficacy of Direct Oral Anticoagulants and Low-Molecular-Weight Heparin in Cancer-Associated Thromboembolism: A Systematic Review and Meta-Analysis.

Cureus. 2023-6-28

[7]
Comparative efficacy and safety profile of once-weekly Semaglutide versus once-daily Sitagliptin as an add-on to metformin in patients with type 2 diabetes: a systematic review and meta-analysis.

Ann Med. 2023

[8]
Clinical Outcomes of Polymer-Free Versus Polymer-Coated Drug-Eluting Stents in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis.

Cureus. 2023-4-27

[9]
Diabetic Peripheral Neuropathy is Associated With Diabetic Kidney Disease and Cardiovascular Disease: The Silesia Diabetes-Heart Project.

Curr Probl Cardiol. 2023-8

[10]
Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis.

Clin Pract. 2023-3-20

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