Wagenseil Jessica E
Department of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., MSC 1185-208-125, St. Louis, MO 63130, USA.
Biomater Biosyst. 2023 Jan 18;9:100072. doi: 10.1016/j.bbiosy.2023.100072. eCollection 2023 Mar.
Thoracic aortic aneurysms and dissections (TAADs) involve dilation of the aortic wall that can lead to tearing or rupture. Progressive extracellular matrix (ECM) degradation is common in TAAD, regardless of the underlying cause. TAAD treatments typically target cellular signaling pathways, rather than the ECM itself, due to the complex assembly process and long half-life of ECM proteins. Compounds that stabilize the ECM are proposed as an alternative TAAD therapy that addresses the underlying cause of aortic wall failure, namely compromised structural integrity. Compounds are discussed that revisit historical approaches to maintain and preserve structural integrity of biological tissues.
胸主动脉瘤和夹层（TAADs）涉及主动脉壁扩张，可导致撕裂或破裂。无论潜在病因如何，细胞外基质（ECM）的渐进性降解在TAAD中都很常见。由于ECM蛋白的组装过程复杂且半衰期长，TAAD治疗通常针对细胞信号通路，而非ECM本身。有人提出，稳定ECM的化合物可作为一种替代TAAD疗法，解决主动脉壁衰竭的根本原因，即结构完整性受损。本文讨论了一些化合物，这些化合物重新审视了维持和保存生物组织结构完整性的历史方法。
