中国儿童呼吸道病毒感染与急性中耳炎关系的病例对照研究。

Case-control study of relationship of infection by respiratory viruses with acute otitis media in Chinese children.

作者信息

Fan Yue, Li Dongdong, Wang Pu, Ren Lili, Chen Xiaowei

机构信息

Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China.

Department of Otolaryngology-Head and Neck Surgery, Xin Jiang Karamay Central Hospital, 834000, China.

出版信息

Heliyon. 2023 Mar 11;9(3):e14422. doi: 10.1016/j.heliyon.2023.e14422. eCollection 2023 Mar.

DOI:10.1016/j.heliyon.2023.e14422

PMID:36967868

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10036650/

Abstract

BACKGROUND

Acute otitis media (AOM) may occur as a complication of viral upper respiratory infection (URI) in children. Our objective was to examine children with URI + AOM or URI alone to determine the association of infection by different common respiratory viruses with AOM.

METHODS

Nasopharyngeal swabs were collected from March 2014 to February 2015. Quantitative PCR was then used to identify the following 10 common respiratory viruses: respiratory syncytial virus (RSV); parainfluenza viruses 1-4 (PIVs); influenza virus type A (IFVA); influenza virus type B; human rhinovirus (HRV); enterovirus; human metapneumovirus; human coronavirus OC43, 229E, NL63, and HKU1; adenovirus; and human bocavirus.

RESULTS

We examined 255 children with URIs (mean age: 32.9 ± 18.7 months), and 164 (64.1%) of them tested positive for at least one respiratory virus. The most common viruses were RSV (44, 24.3%), PIVs (28, 15.5%), and IFVA (25, 13.8%). Positivity for RSV was significantly greater in the URI + AOM group than in the URI group, but these groups did not differ in infection rates for the other 9 viruses. There were also significant seasonal differences in positivity for RSV, IFVA, HRV,HBoV, PIVs and EV.

CONCLUSION

Our results indicated a relationship between infection by common respiratory viruses and AOM in children from Beijing. A URI with RSV significantly increased the risk of AOM in these children.

摘要

背景

急性中耳炎（AOM）可能是儿童病毒性上呼吸道感染（URI）的并发症。我们的目的是研究患有URI+AOM或仅患有URI的儿童，以确定不同常见呼吸道病毒感染与AOM之间的关联。

方法

于2014年3月至2015年2月采集鼻咽拭子。然后使用定量PCR鉴定以下10种常见呼吸道病毒：呼吸道合胞病毒（RSV）；副流感病毒1-4型（PIVs）；甲型流感病毒（IFVA）；乙型流感病毒；人鼻病毒（HRV）；肠道病毒；人偏肺病毒；人冠状病毒OC43、229E、NL63和HKU1；腺病毒；以及人博卡病毒。

结果

我们检查了255名患有URI的儿童（平均年龄：32.9±18.7个月），其中164名（64.1%）至少一种呼吸道病毒检测呈阳性。最常见的病毒是RSV（44例，24.3%）、PIVs（28例，15.5%）和IFVA（25例，13.8%）。URI+AOM组中RSV的阳性率显著高于URI组，但其他9种病毒的感染率在这两组中没有差异。RSV、IFVA、HRV、HBoV、PIVs和EV的阳性率也存在显著的季节性差异。