中性粒细胞与淋巴细胞比值是吉兰-巴雷综合征的一个风险指标，且与病情严重程度及短期预后相关。
Neutrophil-to-lymphocyte ratio is a risk indicator of Guillain-Barré syndrome and is associated with severity and short-term prognosis.
作者信息
Sun Shujun, Wen Yiyong, Li Shu, Huang Zhihua, Zhu Jianming, Li Yandeng
机构信息
Department of Neurology, The First People's Hospital of Changde City, Road 818, Renmin Road, Wuling District, Changde City, Hunan Province, China.
Department of General Practice, The First People's Hospital of Changde City, Road 818, Renmin Road, Wuling District, Changde City, Hunan Province, China.
出版信息
Heliyon. 2023 Mar 10;9(3):e14321. doi: 10.1016/j.heliyon.2023.e14321. eCollection 2023 Mar.
INTRODUCTION
Guillain-Barré syndrome (GBS) is an autoimmune disorder targeting the peripheral nervous system. The neutrophil-to-lymphocyte ratio (NLR), a simple indicator of immune function, is potentially related to its incidence and severity; however, this should be confirmed. We aimed to evaluate the role of NLR in the diagnosis, severity, and prognosis of GBS.
METHODS
Data of GBS patients and controls visiting our hospital from January 2010 to December 2020 were retrospectively analyzed (Clinical trial registration: ChiCTR2100053540). Risk factors were determined through logistic regression. Smoothing curves, receiver-operating characteristic curves, and forest plots were drawn.
RESULTS
We included 136 GBS patients and 211 controls. NLR, as a continuous variable, was associated with GBS risk (OR, 2.32; 95% CI, 1.68-3.21; p < 0.001), severe functional disability (OR, 1.23; 95% CI, 1.06-1.43; p = 0.006), severe weakness (OR, 1.19; 95% CI, 1.06-1.35, p = 0.004), and short-term prognosis (OR, 1.21; 95% CI, 1.08-1.36; p = 0.001). NLR was more strongly associated with GBS risk in older (≥60 years) (OR, 7.17; 95% CI, 2.38-21.61) or male (OR, 2.88; 95% CI, 1.78-4.64) patients than in younger (<60 years) (OR, 1.88; 95% CI, 1.37-2.57) or female (OR, 1.85; 95% CI, 1.24-2.77) patients. NLR was significantly associated with severe functional disability in faster disease progression (OR, 1.53; 95% CI, 1.03-12.29) and male patients (OR, 1.41; 95% CI, 1.03-1.92) versus in slower disease progression (OR, 1.12; 95% CI, 0.77-1.64) and female patients (OR, 1.12; 95% CI, 0.77-1.64).
CONCLUSIONS
NLR may be an independent GBS risk factor and predictor of severe functional disability, severe weakness, and short-term prognosis.
引言
吉兰 - 巴雷综合征（GBS）是一种针对周围神经系统的自身免疫性疾病。中性粒细胞与淋巴细胞比值（NLR）作为免疫功能的一个简单指标，可能与其发病率和严重程度相关；然而，这一点尚需证实。我们旨在评估NLR在GBS诊断、严重程度及预后中的作用。
方法
回顾性分析2010年1月至2020年12月期间来我院就诊的GBS患者及对照的数据（临床试验注册号：ChiCTR2100053540）。通过逻辑回归确定危险因素。绘制平滑曲线、受试者工作特征曲线及森林图。
结果
我们纳入了136例GBS患者和211例对照。NLR作为连续变量，与GBS风险（比值比[OR]，2.32；95%置信区间[CI]，1.68 - 3.21；P < 0.001）、严重功能残疾（OR，1.23；95% CI，1. to 06 - 1.43；P = 0.006）、严重肌无力（OR，1.19；95% CI，1.06 - 1.35，P = 0.004）及短期预后（OR，1.21；95% CI，1.08 - 1.36；P = 0.001）相关。在年龄较大（≥60岁）（OR，7.17；95% CI，2.38 - 21.61）或男性（OR，2.88；95% CI，1.78 - 4.64）患者中，NLR与GBS风险的关联比年龄较小（<60岁）（OR，1.88；95% CI，1.37 - 2.57）或女性（OR，1.85；95% CI，1.24 - 2.77）患者更强。在疾病进展较快（OR，1.53；95% CI，1.03 - 12.29）和男性患者（OR，1.41；95% CI，1.03 - 1.92）中，NLR与严重功能残疾显著相关，而在疾病进展较慢（OR，1.12；95% CI，0.77 - 1.64）和女性患者（OR，1.12；95% CI，0.77 - 1 to 6 to 4）中则不然。
结论
NLR可能是GBS的独立危险因素，以及严重功能残疾、严重肌无力和短期预后的预测指标。
Zotero 插件