自组装金-脱氧核糖核酸纳米机器的进展。
Advances in self-assembled Au-DNA nanomachines.
作者信息
Zhang Qianying, Xu Shengshi, Zheng Jingyi, Zhang Jian-Rong, Zhu Jun-Jie
机构信息
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Shenzhen Research Institute of Nanjing University, Shenzhen 518000, China.
出版信息
iScience. 2023 Mar 3;26(4):106327. doi: 10.1016/j.isci.2023.106327. eCollection 2023 Apr 21.
Au-DNA self-assembled nanomachines can perform intelligent tasks such as sensing biomarkers and delivery of drug molecules through rational customization and programming. By virtue of their efficient signal amplification and flexible scalability, Au-DNA nanomachines have developed into one of the most promising nanodevices. In this review, we summarize the latest progress in Au-DNA self-assembled nanomachines for biosensing applications. First, the functional modules for building Au-DNA nanomachines are introduced. Subsequently, we summarize the biosensing applications of Au-DNA nanomachines with electrochemical or fluorescent signals as the output, respectively. Finally, we discuss the challenges and potential opportunities for Au-DNA nanomachines in biomedical applications.
金-脱氧核糖核酸（Au-DNA）自组装纳米机器可以通过合理定制和编程来执行诸如传感生物标志物和递送药物分子等智能任务。凭借其高效的信号放大和灵活的可扩展性，Au-DNA纳米机器已发展成为最有前途的纳米器件之一。在本综述中，我们总结了用于生物传感应用的Au-DNA自组装纳米机器的最新进展。首先，介绍了构建Au-DNA纳米机器的功能模块。随后，我们分别总结了以电化学或荧光信号作为输出的Au-DNA纳米机器的生物传感应用。最后，我们讨论了Au-DNA纳米机器在生物医学应用中面临的挑战和潜在机遇。
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