Department of General Practice, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Cell Infect Microbiol. 2023 Mar 9;13:1140126. doi: 10.3389/fcimb.2023.1140126. eCollection 2023.
The liver is a vital metabolism and detoxification organ of human body, which is involved in the biotransformation and metabolism of the organism. Hepatitis - cirrhosis - liver cancer are significant and common part of liver diseases. The pathogenesis of liver diseases is generally as followed: inflammation and other pathogenic factors cause persistent damage to the liver, leading to the activation of hepatic stellate cells (HSCs) and excessive deposition of extracellular matrix. Patients with chronic hepatitis have a high risk of developing into liver fibrosis, cirrhosis, and even life-threatening liver cancer, which poses a great threat to public health.As the first organ to come into contact with blood from the gut, the liver is profoundly affected by the intestinal flora and its metabolites, with leaky gut and flora imbalance being the triggers of the liver's pathological response. So far, no one has reviewed the role of intestinal flora in this process from the perspective of the progression of hepatitis-cirrhosis-liver cancer and this article reviews the evidence supporting the effect of intestinal flora in the progression of liver disease.
肝脏是人体重要的代谢和解毒器官，参与机体的生物转化和代谢。肝炎-肝硬化-肝癌是肝脏疾病中重要且常见的部分。肝脏疾病的发病机制一般为：炎症等致病因素导致肝脏持续损伤，进而激活肝星状细胞（HSCs）并过度沉积细胞外基质。慢性肝炎患者发展为肝纤维化、肝硬化甚至危及生命的肝癌的风险较高，这对公众健康构成了巨大威胁。由于肝脏是首先与肠道血液接触的器官，因此其受到肠道菌群及其代谢产物的深刻影响，肠漏和菌群失衡是肝脏病理反应的触发因素。到目前为止，还没有人从肝炎-肝硬化-肝癌进展的角度综述肠道菌群在这一过程中的作用，本文综述了支持肠道菌群在肝病进展中发挥作用的证据。
