Ding Yang, Yang Huan, Gao Jie, Tang Can, Peng Yu-Yuan, Ma Xin-Mei, Li Sen, Wang Hai-Yan, Lu Xiu-Min, Wang Yong-Tang
College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Mol Cell Biochem. 2025 Jun;480(6):3399-3411. doi: 10.1007/s11010-025-05209-y. Epub 2025 Jan 22.
Synaptic plasticity is the basis for the proper functioning of the central nervous system. Synapses are the contact points between neurons and are crucial for information transmission, the structure and function of synapses change adaptively based on the different activities of neurons, thus affecting processes such as learning, memory, and neural development and repair. Synaptic activity requires a large amount of energy provided by mitochondria. Mitochondrial transport proteins regulate the positioning and movement of mitochondria to maintain normal energy metabolism. Recent studies have shown a close relationship between mitochondrial transport proteins and synaptic plasticity, providing a new direction for the study of adaptive changes in the central nervous system and new targets for the treatment of neurodegenerative diseases.
突触可塑性是中枢神经系统正常运作的基础。突触是神经元之间的接触点，对信息传递至关重要，突触的结构和功能会根据神经元的不同活动而适应性地改变，从而影响学习、记忆以及神经发育和修复等过程。突触活动需要线粒体提供大量能量。线粒体转运蛋白调节线粒体的定位和移动，以维持正常的能量代谢。最近的研究表明线粒体转运蛋白与突触可塑性之间存在密切关系，为中枢神经系统适应性变化的研究提供了新方向，也为神经退行性疾病的治疗提供了新靶点。
