Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Mol Med Rep. 2025 Jan;31(1). doi: 10.3892/mmr.2024.13375. Epub 2024 Oct 25.
Incidence of a number of liver diseases has increased. Gut microbiota serves a role in the pathogenesis of hepatitis, cirrhosis and liver cancer. Gut microbiota is considered 'a new virtual metabolic organ'. The interaction between the gut microbiota and liver is termed the gut‑liver axis. The gut‑liver axis provides a novel research direction for mechanism of liver disease development. The present review discusses the role of the gut‑liver axis and how this can be targeted by novel treatments for common liver diseases.
一些肝脏疾病的发病率有所增加。肠道微生物群在肝炎、肝硬化和肝癌的发病机制中起作用。肠道微生物群被认为是“新的虚拟代谢器官”。肠道微生物群与肝脏的相互作用被称为肠-肝轴。肠-肝轴为肝脏疾病发展的机制提供了一个新的研究方向。本综述讨论了肠-肝轴的作用，以及如何通过针对常见肝脏疾病的新型治疗方法来靶向该轴。
