Zhang Xiaomei, Li Yanqing, Zhang Dandan, Zhong Yueping, Li Tian
Department of Neurosurgery, Affiliated Hospital of Nantong University, 20th Xisi Road, Nantong 226001, China.
Medical College, Nantong University, 19th Qixiu Road, Nantong 226001, China.
J Oncol. 2023 Mar 15;2023:9876422. doi: 10.1155/2023/9876422. eCollection 2023.
Pituitary adenomas (PAs) refers to a group of benign tumors that develop in the pituitary gland and are often characterized by fatigue. However, fatigue has not been documented in any Chinese research involving people with primary PA. The study sought to examine the prevalence, predictors, and correlation of fatigue with the quality of life (QoL) among PA patients in China.
In total, 203 primary PA patients were included in this cross-sectional study. A series of questionnaires were administered, including the Multidimensional Fatigue Inventory (MFI), M. D. Anderson Symptom Inventory Brain Tumor (MDASI-BT), Short-Form 36 Health Survey (SF-36), Pittsburgh Sleep Quality Index (PSQI), and the Hospital Anxiety and Depression Scale (HADS). Data analysis was accomplished by Pearson or Spearman correlations, linear regression, and simple path analysis.
Severe fatigue prior to the initial diagnosis and preparation for surgery affected 50% of PA patients. Depression, sleep disturbance, and MDASI-BT symptom total scores were independently able to predict patient fatigue. Sleep disturbance mediates the influence of depression on fatigue (IE sleep = 0.296, 95% CI: LB = 0.148 to UB = 0.471).
Chinese patients with primary PA often report experiencing fatigue. Depression and poor sleep quality were shown to be significant contributors to PA patients' fatigue. Depression affects PA patients' fatigue directly or indirectly. Medical professionals should take a proactive approach to PA patients suffering from fatigue before initial diagnosis and preoperative preparation to determine necessary interventions early, thus reducing fatigue and ultimately enhancing their QoL.
垂体腺瘤（PAs）是指发生于垂体腺的一组良性肿瘤，常伴有疲劳症状。然而，在中国，尚无任何涉及原发性垂体腺瘤患者的研究记录过疲劳情况。本研究旨在调查中国垂体腺瘤患者疲劳的患病率、预测因素以及疲劳与生活质量（QoL）之间的相关性。
本横断面研究共纳入203例原发性垂体腺瘤患者。采用了一系列问卷，包括多维疲劳量表（MFI）、MD安德森症状问卷脑瘤版（MDASI-BT）、简明健康状况调查量表（SF-36）、匹兹堡睡眠质量指数（PSQI）以及医院焦虑抑郁量表（HADS）。数据分析通过Pearson或Spearman相关性分析、线性回归和简单路径分析完成。
在初次诊断和术前准备之前，50%的垂体腺瘤患者存在严重疲劳。抑郁、睡眠障碍和MDASI-BT症状总分能够独立预测患者的疲劳情况。睡眠障碍介导了抑郁对疲劳的影响（间接效应睡眠=0.296，95%置信区间：下限=0.148至上限=0.471）。
中国原发性垂体腺瘤患者常报告有疲劳经历。抑郁和睡眠质量差是垂体腺瘤患者疲劳的重要因素。抑郁直接或间接影响垂体腺瘤患者的疲劳。医疗专业人员应在初次诊断和术前准备之前，对患有疲劳的垂体腺瘤患者采取积极措施，尽早确定必要的干预措施，从而减轻疲劳并最终提高他们的生活质量。
