Department of Nursing, Affiliated Hospital of Nantong University, 20th Xisi Road, Nantong, 226001, China.
Department of Rheumatology, Affiliated Hospital of Nantong University, 20th Xisi Road, Nantong, 226001, Jiangsu, People's Republic of China.
Clin Rheumatol. 2020 Aug;39(8):2337-2344. doi: 10.1007/s10067-020-04976-x. Epub 2020 Mar 5.
Fatigue is a common symptom in patients with ankylosing spondylitis (AS). However, fatigue of AS patients has not been well elucidated in China. This study aimed to evaluate the predictors of fatigue and the effects of fatigue on health-related quality of life among patients with AS.
A total of 150 AS patients were involved in the study. A series of questionnaires included the following: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), the 10-cm Visual Analog Scale (VAS), the Self-Rating Anxiety Scale (SAS), the Self-Rating Depression Scale (SDS), the Pittsburgh Sleep Quality Index (PSQI), the Health Assessment Questionnaire-Disability Index (HAQ-DI), the Short Form 36 Health Survey (SF-36), and the Fatigue Severity Scale (FSS). Independent samples t test, Mann-Whitney U test, chi-square analysis, Pearson/Spearman correlation, and binary logistic regression were used to analyze the data.
The results demonstrated that 48.7% individuals with AS suffered from fatigue. Binary logistic regression indicated that waist-to-hip ratio, BASDAI, and sleep disturbance were independent predictors of fatigue in AS patients. Meanwhile, severe fatigue led to lower quality of life.
These findings suggested that medical personnel should pay more attention to AS patients with fatigue and take effective measures to relieve fatigue. Key Points • Incidence of fatigue in AS patients is 48.7% according to this cross-sectional study. • The occurrence of fatigue was associated with higher WHR, higher BASDAI, and sleep disturbance. • We also found that the occurrence of fatigue significantly reduced the quality of life in AS patients both physically and psychologically.
疲劳是强直性脊柱炎（AS）患者的常见症状。然而，中国尚未充分阐明 AS 患者的疲劳情况。本研究旨在评估 AS 患者疲劳的预测因素，以及疲劳对 AS 患者健康相关生活质量的影响。
本研究共纳入 150 例 AS 患者。使用一系列问卷评估患者，包括 Bath 强直性脊柱炎疾病活动指数（BASDAI）、Bath 强直性脊柱炎衡量指数（BASMI）、Bath 强直性脊柱炎功能指数（BASFI）、10cm 视觉模拟量表（VAS）、焦虑自评量表（SAS）、抑郁自评量表（SDS）、匹兹堡睡眠质量指数（PSQI）、健康评估问卷残疾指数（HAQ-DI）、简明健康调查问卷 36 项（SF-36）和疲劳严重程度量表（FSS）。采用独立样本 t 检验、Mann-Whitney U 检验、卡方分析、Pearson/Spearman 相关分析和二元逻辑回归分析进行数据分析。
结果表明，48.7%的 AS 患者存在疲劳。二元逻辑回归表明，腰臀比、BASDAI 和睡眠障碍是 AS 患者疲劳的独立预测因素。同时，严重的疲劳会导致生活质量下降。
这些发现表明，医务人员应更加关注患有疲劳的 AS 患者，并采取有效措施缓解疲劳。关键点 • 本横断面研究显示，AS 患者疲劳的发生率为 48.7%。 • 疲劳的发生与较高的 WHR、较高的 BASDAI 和睡眠障碍有关。 • 我们还发现，疲劳的发生显著降低了 AS 患者的身心健康相关生活质量。
