Mao Sanying, Hu Yuanhong, Zheng Xingwu, Yang Chengmin, Yang Meiling, Li Xianghong, Shang Jingwei, Abe Koji
Department of Neurology, The First People's Hospital of Jiande, Hangzhou, China.
Guilin Medical University, Guilin, China.
Cardiol Cardiovasc Med. 2023;7(1):32-38. doi: 10.26502/fccm.92920305. Epub 2023 Feb 13.
Ischemic stroke (IS) is a common neurological disease in the elderly, but the relationship between neutrophil/albumin ratio (NAR) and leukocyte count/albumin ratio (LAR) and the severity of neurological function injury and early neurological deterioration (END) occurrence remain elusive in acute IS. A total of 299 patients with acute IS and 56 healthy controls were enrolled. According to the NIHSS score at admission, the disease group was divided into three groups (mild, moderate and severe IS), and the differences in five indexes NAR, LAR, neutrophil count, leukocyte count and albumin among the four groups were analyzed. Furthermore, explore the correlation between the above indicators and the severity of IS and END occurrence. The results showed that higher NAR, LAR, neutrophil count, leukocyte count levels and lower albumin levels were associated with acute IS, and the levels of NAR and LAR increased gradually in three groups of IS. NAR and LAR were positively and albumin was negatively correlated with the severity of IS. Meanwhile, NAR and LAR showed a good predictive value in identifying patients with END after acute IS. NAR and LAR may be predictors of the severity of IS and END occurrence after acute IS.
缺血性中风(IS)是老年人常见的神经系统疾病,但在急性缺血性中风中,中性粒细胞/白蛋白比值(NAR)和白细胞计数/白蛋白比值(LAR)与神经功能损伤严重程度及早期神经功能恶化(END)发生之间的关系仍不明确。共纳入299例急性缺血性中风患者和56例健康对照者。根据入院时美国国立卫生研究院卒中量表(NIHSS)评分,将疾病组分为三组(轻度、中度和重度缺血性中风),分析四组间中性粒细胞/白蛋白比值、白细胞计数/白蛋白比值、中性粒细胞计数、白细胞计数和白蛋白这五个指标的差异。此外,探讨上述指标与缺血性中风严重程度及END发生之间的相关性。结果显示,较高的中性粒细胞/白蛋白比值、白细胞计数/白蛋白比值、中性粒细胞计数、白细胞计数水平及较低的白蛋白水平与急性缺血性中风相关,且在三组缺血性中风患者中,中性粒细胞/白蛋白比值和白细胞计数/白蛋白比值水平逐渐升高。中性粒细胞/白蛋白比值和白细胞计数/白蛋白比值与缺血性中风严重程度呈正相关,白蛋白与之呈负相关。同时,中性粒细胞/白蛋白比值和白细胞计数/白蛋白比值在识别急性缺血性中风后发生END的患者方面具有良好的预测价值。中性粒细胞/白蛋白比值和白细胞计数/白蛋白比值可能是急性缺血性中风严重程度及END发生的预测指标。