动脉粥样硬化：最新进展。
Atherosclerosis: Recent developments.
机构信息
Department of Genetics and Genomic Sciences, Division of Cardiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Department of Medicine/Division of Cardiology, Department of Microbiology, Immunology and Molecular Genetics, Department of Human Genetics, A2-237 Center for the Health Sciences, University of California, Los Angeles, Los Angeles, CA USA.
出版信息
Cell. 2022 May 12;185(10):1630-1645. doi: 10.1016/j.cell.2022.04.004. Epub 2022 May 2.
Abstract
Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.
摘要
动脉粥样硬化是一种大动脉硬化的炎症性疾病，是心血管疾病 (CVD) 和中风的主要病因。在这里，我们从个体途径和系统角度回顾了目前对动脉粥样硬化的分子、细胞、遗传和环境贡献的理解。我们强调了最近的一些发展，其中一些发展产生了意想不到的生物学，包括动脉粥样硬化病变中炎症细胞和平滑肌细胞以前未知的异质性、衰老和克隆性造血的作用，以及与肠道微生物组的联系。
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