Abdel-Zaher Souzan, Mohamed Mahmoud S, Sayed Alaa El-Din H
Department of Molecular Biology, Molecular Biology Researches and Studies Institute, Assiut University, Assiut, Egypt.
Zoology Department, Faculty of Science, Assiut University, Assiut, Egypt.
Front Physiol. 2023 Mar 8;14:1072797. doi: 10.3389/fphys.2023.1072797. eCollection 2023.
Micro- or nanoplastics, which are fragmented or otherwise tiny plastic materials, have long been a source of environmental worry. Microplastics (MPs) have been well documented to alter the physiology and behavior of marine invertebrates. The effects of some of these factors are also seen in larger marine vertebrates, such as fish. More recently, mouse models have been used to investigate the potential impacts of micro- and nanoplastics on host cellular and metabolic damages as well as mammalian gut flora. The impact on erythrocytes, which carry oxygen to all cells, has not yet been determined. Therefore, the current study aims to ascertain the impact of exposure to various MP exposure levels on hematological alterations and biochemical indicators of liver and kidney functions. In this study, a C57BL/6 murine model was concentration-dependently exposed to microplastics (6, 60, and 600 μg/day) for 15 days, followed by 15 days of recovery. The results demonstrated that exposure to 600 μg/day of MPs considerably impacted RBCs' typical structure, resulting in numerous aberrant shapes. Furthermore, concentration-dependent reductions in hematological markers were observed. Additional biochemical testing revealed that MP exposure impacted the liver and renal functioning. Taken together, the current study reveals the severe impacts of MPs on mouse blood parameters, erythrocyte deformation, and consequently, anemic patterns of the blood.
微塑料或纳米塑料，即破碎的或其他微小的塑料材料，长期以来一直是环境问题的根源。微塑料（MPs）已被充分证明会改变海洋无脊椎动物的生理和行为。其中一些因素的影响在较大的海洋脊椎动物，如鱼类中也有体现。最近，小鼠模型已被用于研究微塑料和纳米塑料对宿主细胞和代谢损伤以及哺乳动物肠道菌群的潜在影响。对将氧气输送到所有细胞的红细胞的影响尚未确定。因此，本研究旨在确定暴露于不同水平的微塑料对血液学改变以及肝脏和肾脏功能生化指标的影响。在本研究中，C57BL/6小鼠模型以浓度依赖的方式暴露于微塑料（6、60和600μg/天）15天，随后恢复15天。结果表明，每天暴露于600μg的微塑料对红细胞的典型结构有相当大的影响，导致大量异常形状出现。此外，观察到血液学指标呈浓度依赖性降低。进一步的生化测试表明，微塑料暴露影响了肝脏和肾脏功能。综上所述，本研究揭示了微塑料对小鼠血液参数、红细胞变形以及由此导致的血液贫血模式的严重影响。
