Lv Yue, Wang Zhen, Yuan Kefei
Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
J Clin Transl Hepatol. 2023 Jun 28;11(3):682-694. doi: 10.14218/JCTH.2022.00412. Epub 2023 Jan 19.
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies. It has high mortality and poor clinical outcomes, but the molecular mechanisms in the pathogenesis of HCC are not understood. The tumor immune microenvironment (TIME) is a highly intricate system with distinct populations of innate and adaptive immune cells, as well as other stromal cells. They interact and evolve with tumor cells to influence tumor growth, migration, invasion, immune evasion, and response to therapy. Emerging evidence has shown noncoding RNAs (ncRNAs) are prominent regulators of TIME in HCC. In this review, we elaborate on the functions and molecular mechanisms of ncRNAs in remodeling TIME of HCC and discuss their diagnostic and therapeutic potential for HCC treatment.
肝细胞癌（HCC）是最常见的恶性肿瘤之一。它具有高死亡率和较差的临床预后，但HCC发病机制中的分子机制尚不清楚。肿瘤免疫微环境（TIME）是一个高度复杂的系统，由不同群体的先天性和适应性免疫细胞以及其他基质细胞组成。它们与肿瘤细胞相互作用并共同进化，以影响肿瘤的生长、迁移、侵袭、免疫逃逸及对治疗的反应。新出现的证据表明，非编码RNA（ncRNAs）是HCC中TIME的重要调节因子。在本综述中，我们阐述了ncRNAs在重塑HCC的TIME中的功能和分子机制，并讨论了它们在HCC治疗中的诊断和治疗潜力。
