Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Department of Postanesthesia Care Unit & Surgical Anesthesia Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Int J Cancer. 2022 Aug 1;151(3):337-347. doi: 10.1002/ijc.34040. Epub 2022 May 11.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Metabolic reprogramming is considered to be an important hallmark of cancer. Emerging studies have demonstrated that noncoding RNAs (ncRNAs) are closely associated with metabolic reprogramming of HCC. NcRNAs can directly regulate the expressions or functions of metabolic enzymes or indirectly regulate the metabolism of HCC cells through some vital signaling pathways. Until now, the mechanisms of HCC development and progression remain largely unclear, and understanding the regulatory mechanism of ncRNAs on metabolic reprogramming of HCC may provide an important basis for breakthrough progress in the treatment of HCC. In this review, we summarize the ncRNAs involved in regulating metabolic reprogramming of HCC. Specifically, the regulatory roles of ncRNAs in glucose, lipid and amino acid metabolism are elaborated. In addition, we discuss the molecular mechanism of ncRNAs in regulation of metabolic reprogramming and possible therapeutic strategies that target the metabolism of cancer cells by modulating the expressions of specific ncRNAs.
肝细胞癌（HCC）是最常见的原发性肝癌。代谢重编程被认为是癌症的一个重要标志。新兴的研究表明，非编码 RNA（ncRNA）与 HCC 的代谢重编程密切相关。ncRNA 可以直接调节代谢酶的表达或功能，或通过一些重要的信号通路间接调节 HCC 细胞的代谢。到目前为止，HCC 发展和进展的机制在很大程度上仍不清楚，了解 ncRNA 对 HCC 代谢重编程的调控机制可能为 HCC 治疗的突破性进展提供重要依据。在这篇综述中，我们总结了参与调节 HCC 代谢重编程的 ncRNA。具体来说，阐述了 ncRNA 在葡萄糖、脂质和氨基酸代谢中的调节作用。此外，我们还讨论了 ncRNA 调节代谢重编程的分子机制，以及通过调节特定 ncRNA 的表达来靶向癌细胞代谢的可能治疗策略。
