Mikziński Paweł, Kraus Karolina, Seredyński Rafał, Widelski Jarosław, Paluch Emil
Faculty of Medicine, Wroclaw Medical University, Wyb. Pasteura 1, 50-376 Wroclaw, Poland.
Department of Physiology and Pathophysiology, Wroclaw Medical University, Tytusa Chałubińskiego 10, 50-368 Wroclaw, Poland.
Molecules. 2025 May 26;30(11):2323. doi: 10.3390/molecules30112323.
Photocatalysis and photodynamic therapy have been increasingly used in the management of diabetic foot ulcers (DFUs), and their integration into increasingly innovative treatment protocols enables effective infection control. Advanced techniques such as antibacterial photodynamic therapy (aPDT), liposomal photocatalytic carriers, nanoparticles, and nanomotors-used alone, in combination, or with the addition of antibiotics, lysozyme, or phage enzymes-offer promising solutions for wound treatment. These approaches are particularly effective even in the presence of comorbidities such as angiopathies, neuropathies, and immune system disorders, which are common among diabetic patients. Notably, the use of combination therapies holds great potential for addressing challenges within diabetic foot ulcers, including hypoxia, poor circulation, high glucose levels, increased oxidative stress, and rapid biofilm formation-factors that significantly hinder wound healing in diabetic patients. The integration of modern therapeutic strategies is essential for effective clinical practice, starting with halting infection progression, ensuring its effective eradication, and promoting proper tissue regeneration, especially considering that, according to the WHO, 830 million people worldwide suffer from diabetes.
光催化和光动力疗法在糖尿病足溃疡（DFUs）的治疗中应用越来越广泛，将它们纳入日益创新的治疗方案能够有效控制感染。诸如抗菌光动力疗法（aPDT）、脂质体光催化载体、纳米颗粒和纳米马达等先进技术——单独使用、联合使用或与抗生素、溶菌酶或噬菌体酶联用——为伤口治疗提供了有前景的解决方案。即使在糖尿病患者中常见的诸如血管病变、神经病变和免疫系统紊乱等合并症存在的情况下，这些方法也特别有效。值得注意的是，联合疗法在应对糖尿病足溃疡中的挑战方面具有巨大潜力，这些挑战包括缺氧、血液循环不良、高血糖水平、氧化应激增加以及生物膜快速形成——这些因素显著阻碍糖尿病患者伤口愈合。现代治疗策略的整合对于有效的临床实践至关重要，首先要阻止感染进展，确保有效根除感染，并促进适当的组织再生，尤其是考虑到据世界卫生组织称，全球有8.3亿人患有糖尿病。
