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镰状细胞病患者中的脂肪栓子与危重症相关脑微出血(CICMs):这两种情况会同时存在吗?

Fat emboli and critical illness-associated cerebral microbleeds (CICMs) in a patient with sickle cell disease: Do these 2 entities coexist?

作者信息

Mohammed-Hadj Selsabil, Colard Martin, Delpierre Isabelle, Taccone Fabio, Lolli Valentina Elisabetta

机构信息

Radiology Department, CUB-Hôpital Erasme, 808 route de Lennik, 1070 Brussels, Belgium.

Onco-hematology Department, CUB-Hôpital Erasme, 808 route de Lennik, 1070 Brussels, Belgium.

出版信息

Radiol Case Rep. 2023 Mar 20;18(5):1978-1981. doi: 10.1016/j.radcr.2023.02.044. eCollection 2023 May.

DOI:10.1016/j.radcr.2023.02.044
PMID:36970237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10034566/
Abstract

We report the case of a 30-year-old female patient with sickle cell disease presenting with an acute chest syndrome and neurological deterioration. Cerebral magnetic resonance imaging revealed a handful of foci of diffusion restriction and numerous microbleeds with marked involvement of corpus callosum and subcortical white matter, with relative sparing of the cortex and deep white matter. Corpus callosum-predominant and juxtacortical microbleeds have been typically documented in cerebral fat embolism syndrome, but also in the so-called "critical-illness-associated cerebral microbleeds", a recently described entity associated with respiratory failure. We discussed whether these 2 entities may coexist.

摘要

我们报告了一名30岁患有镰状细胞病的女性患者,该患者出现急性胸综合征和神经功能恶化。脑部磁共振成像显示有少量弥散受限灶和大量微出血,胼胝体和皮质下白质明显受累,皮质和深部白质相对 spared。胼胝体为主型和皮质旁微出血通常在脑脂肪栓塞综合征中被记录到,但在所谓的“危重症相关性脑微出血”中也有记录,这是一种最近描述的与呼吸衰竭相关的实体。我们讨论了这两种实体是否可能共存。 (注:spared这个词原文有误,推测可能是spared,暂按“ spared”翻译为“ spared”,请确认原文准确内容)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/10034566/f4056c294e46/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/10034566/f4056c294e46/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/10034566/f4056c294e46/gr1.jpg

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本文引用的文献

1
Microbleeds show a characteristic distribution in cerebral fat embolism.微出血在脑脂肪栓塞中呈现出特征性分布。
Insights Imaging. 2021 Mar 31;12(1):42. doi: 10.1186/s13244-021-00988-6.
2
COVID-19-associated Diffuse Leukoencephalopathy and Microhemorrhages.COVID-19 相关弥漫性脑白质病和微出血。
Radiology. 2020 Oct;297(1):E223-E227. doi: 10.1148/radiol.2020202040. Epub 2020 May 21.
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Pediatric critical illness associated cerebral microhemorrhages.小儿危重症相关性脑微出血
eNeurologicalSci. 2019 Dec 24;18:100221. doi: 10.1016/j.ensci.2019.100221. eCollection 2020 Mar.
4
Sickle cell disease, fat embolism syndrome, and "starfield" pattern on MRI.镰状细胞病、脂肪栓塞综合征与MRI上的“星芒状”表现
Neurol Clin Pract. 2018 Apr;8(2):162-164. doi: 10.1212/CPJ.0000000000000443.
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Cerebral Microbleeds: Imaging and Clinical Significance.脑微出血:影像学表现与临床意义。
Radiology. 2018 Apr;287(1):11-28. doi: 10.1148/radiol.2018170803.
6
Cerebral Fat Embolism: Clinical Presentation, Diagnostic Steps and Long-Term Follow-Up.脑脂肪栓塞:临床表现、诊断步骤及长期随访
Eur Neurol. 2017;78(3-4):181-187. doi: 10.1159/000479002. Epub 2017 Sep 12.
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Uncommon Causes of Cerebral Microbleeds.脑微出血的罕见病因
J Stroke Cerebrovasc Dis. 2017 Oct;26(10):2043-2049. doi: 10.1016/j.jstrokecerebrovasdis.2017.07.012. Epub 2017 Aug 18.
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Critical Illness-Associated Cerebral Microbleeds.危重症相关性脑微出血
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