Shah Heer, Mistry Mittal, Patel Nupur, Vora Hemangini
Immunohematology Laboratory, Cancer Biology Department, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India.
Breast Dis. 2023;42(1):85-100. doi: 10.3233/BD-220041.
The Notch signaling pathway is an evolutionary conserved cell signaling pathway that plays an indispensable role in essential developmental processes. Aberrant activation of Notch pathway is known to initiate wide array of diseases and cancers.
To evaluate the clinical significance of Notch receptors in Triple Negative Breast Cancer.
We evaluated the association between Notch receptors and clinicopathological parameters including disease-free survival and overall survival of one hundred TNBC patients by immunohistochemistry.
Positive expression of nuclear Notch1 receptor (18%) was found be significantly correlated with positive lymph node (p = 0.009), high BR score (p = 0.02) and necrosis (p = 0.004) while cytoplasmic expression of Notch2 receptor (26%) was significantly correlated with metastasis (p = 0.05), worse DFS (p = 0.05) and poor OS (p = 0.02) in TNBC patients. Membrane (18%) and cytonuclear (3%) Notch3 expression were significantly associated with poorly differentiated tumors (p = 0.007), high BR score (p = 0.002) and necrosis (p = 0.03) respectively. However, cytoplasmic Notch3 and Notch4 expression were negatively correlated with poor prognostic factors.
Our data indicated that Notch receptors play a key role in promoting TNBC and mainly, Notch2 may contribute to poor prognosis of the disease. Hence, it is implicated that Notch2 may serve as a potential biomarker and therapeutic target for TNBC.
Notch信号通路是一条在进化上保守的细胞信号通路，在重要的发育过程中发挥着不可或缺的作用。已知Notch通路的异常激活会引发多种疾病和癌症。
评估Notch受体在三阴性乳腺癌中的临床意义。
我们通过免疫组织化学评估了100例三阴性乳腺癌患者的Notch受体与临床病理参数（包括无病生存期和总生存期）之间的关联。
发现核Notch1受体的阳性表达（18%）与阳性淋巴结（p = 0.009）、高BR评分（p = 0.02）和坏死（p = 0.004）显著相关，而Notch2受体的细胞质表达（26%）与三阴性乳腺癌患者的转移（p = 0.05）、较差的无病生存期（p = 0.05）和较差的总生存期（p = 0.02）显著相关。膜性（18%）和细胞核（3%）Notch3表达分别与低分化肿瘤（p = 0.007）、高BR评分（p = 0.002）和坏死（p = 0.03）显著相关。然而，细胞质Notch3和Notch4表达与不良预后因素呈负相关。
我们的数据表明，Notch受体在促进三阴性乳腺癌中起关键作用，主要是Notch2可能导致该疾病的预后不良。因此，提示Notch2可能作为三阴性乳腺癌的潜在生物标志物和治疗靶点。
