De Stefano Ludovico, D'Onofrio Bernardo, Gandolfo Saviana, Bozzalla Cassione Emanuele, Mauro Daniele, Manzo Antonio, Ciccia Francesco, Bugatti Serena
Department of Internal Medicine and Therapeutics, Università di Pavia, and Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
U.O. di Reumatologia, Ospedale San Giovanni Bosco, Napoli, Italy.
Clin Exp Rheumatol. 2023 Mar;41(3):554-564. doi: 10.55563/clinexprheumatol/go7g26. Epub 2023 Mar 23.
In the past 20 years, earlier diagnosis and more intensive management have considerably improved the prognosis of rheumatoid arthritis (RA), with milder disease course achieved in particular in seropositive patients. In contrast, seronegative RA has remained largely neglected, and continues to be surrounded by uncertainties regarding its correct diagnosis, clinical phenotype, optimal treatment strategies and relevant outcomes.The purpose of this review is to summarise new insights about the pathogenic, clinical and prognostic peculiarities of seronegative RA that emerged during 2022, and that make this disease subset at least partially different from its seropositive counterpart.
在过去20年中，早期诊断和更强化的管理显著改善了类风湿关节炎（RA）的预后，尤其是血清学阳性患者的病程更为轻微。相比之下，血清学阴性RA在很大程度上仍被忽视，在正确诊断、临床表型、最佳治疗策略及相关结局方面仍存在诸多不确定性。本综述的目的是总结2022年出现的关于血清学阴性RA的发病机制、临床和预后特点的新见解，这些见解使该疾病亚组至少在部分方面与其血清学阳性对应物有所不同。
