基于语义的记忆编码策略和认知刺激对轻度认知障碍老年人认知功能和日常任务表现的影响：一项初步的非随机对照聚类临床试验。

Semantic-based memory-encoding strategy and cognitive stimulation in enhancing cognitive function and daily task performance for older adults with mild cognitive impairment: A pilot non-randomised cluster controlled trial.

机构信息

School of Health Sciences, Western Sydney University, Sydney, Australia.

Christian Family Service Centre, Kwun Tong, Hong Kong.

出版信息

PLoS One. 2023 Mar 27;18(3):e0283449. doi: 10.1371/journal.pone.0283449. eCollection 2023.

DOI:10.1371/journal.pone.0283449

PMID:36972279

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10042350/

Abstract

AIM

To investigate the effectiveness of a semantic-based memory-encoding strategy intervention and cognitive stimulation that enhances function for older adults with mild cognitive impairment.

METHODS

A two-armed single-blind non-randomised cluster controlled trial was conducted. Participants in two centres were allocated to the semantic-based memory-encoding experimental group and those in the other two centres received cognitive stimulation. In both groups, one centre- or community-based session and one home-based session were provided weekly for 10 weeks. Outcome measures included attention, memory and general cognitive function (Word List Memory and Word List Recall of the Consortium to Establish a Registry for the Alzheimer's disease, Digit Span Forwards and Backwards and the Cognistat), and daily task performance (Disability Assessment for Dementia and Lawton Instrumental Activities of Daily Living Scale). They were administered pre- and post-intervention.

RESULTS

Thirty-nine participants completed the study. No significant differences were revealed in the demographic or baseline data. The experimental group showed significant improvements in daily task performance (Disability Assessment for Dementia; p = 0.003), memory outcomes (Word List Recall; p < 0.001), general cognitive function (Cognistat subtests of Memory and Similarity; ps = 0.002 and < 0.001). The cognitive stimulation control group did not show any significant improvement in the measures. Between-group analysis showed significant differences in favour of the experimental group for the outcome measures of the Word List Recall and Cognistat Similarity subtest (ps < 0.001).

CONCLUSIONS

This study shows that the semantic-based memory-encoding strategy is more superior than cognitive stimulation with improvements in attention, memory, general cognitive function and daily task performance for people with a mild cognitive impairment.

TRIAL REGISTRATION

ClinicalTrials.gov Protocol Registration and Results System (NCT02953964).

摘要

目的

调查基于语义的记忆编码策略干预和认知刺激对轻度认知障碍老年人功能的增强效果。

方法

采用双臂单盲非随机对照聚类临床试验。两个中心的参与者被分配到基于语义的记忆编码实验组，而其他两个中心的参与者接受认知刺激。在两组中，每周提供一次中心或社区为基础的课程和一次家庭为基础的课程，共 10 周。结果测量包括注意力、记忆和一般认知功能（阿尔茨海默病研究联合会的单词列表记忆和单词列表回忆、数字广度向前和向后以及认知状态）以及日常任务表现（痴呆残疾评估和劳顿日常生活活动量表）。它们在干预前后进行了评估。

结果

39 名参与者完成了研究。在人口统计学或基线数据方面没有发现显著差异。实验组在日常任务表现（痴呆残疾评估；p = 0.003）、记忆结果（单词列表回忆；p < 0.001）、一般认知功能（认知状态记忆和相似性子测试；p = 0.002 和 < 0.001）方面均显示出显著改善。认知刺激对照组在这些测量指标上没有显示出任何显著的改善。组间分析显示，实验组在单词列表回忆和认知状态相似性子测试的结果测量方面具有显著优势（p < 0.001）。