Paz Manuel M, Veiga Alberto Peinador, Regueira Tamara, Vázquez Carlos Vázquez, Arturo López Quintela M
Instituto de Materiais (iMATUS), Facultade de Química, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain; Departamento de Química Orgánica, Facultade de Química, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Departamento de Química Orgánica, Facultade de Química, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
J Colloid Interface Sci. 2023 Jul;641:719-728. doi: 10.1016/j.jcis.2023.03.043. Epub 2023 Mar 10.
Surface chemistry is a key determinant of the physico-chemical and biological properties of gold nanoparticles (AuNPs). The introduction of chemical diversity in the surface of AuNPs is usually accomplished by place-exchange reactions using incoming ligands containing the desired terminal functional groups. As an alternative approach, we present here a simple, practical methodology to modify the surface of gold nanoparticles that allows the preparation of AuNPs stabilized with polyethyleneglycol (PEG) ligands with different surface chemistries using AuNPs stabilized with thiol-PEG-amino ligands as starting material. The surface modification reaction involves the acylation of the terminal amino groups in the ligand with an organic acid anhydride in an aqueous buffer. In addition to a full surface modification, this method also allows the synthesis of AuNPs with tailored mixed surfaces, containing two or more different functional groups, each of them at the desired extent. The ease of the experimental conditions for the reaction, purification, and for determining the level of surface modification makes this strategy an attractive alternative to current methods for the preparation of AuNPs with diverse surface chemistry.
表面化学是金纳米颗粒（AuNPs）物理化学和生物学性质的关键决定因素。在AuNPs表面引入化学多样性通常是通过使用含有所需末端官能团的引入配体进行配体交换反应来实现的。作为一种替代方法，我们在此提出一种简单、实用的方法来修饰金纳米颗粒的表面，该方法允许以硫醇-聚乙二醇-氨基配体稳定的AuNPs为起始材料，制备具有不同表面化学性质的聚乙二醇（PEG）配体稳定的AuNPs。表面修饰反应涉及在水性缓冲液中用有机酸酐将配体中的末端氨基进行酰化。除了完全表面修饰外，该方法还允许合成具有定制混合表面的AuNPs，其包含两个或更多不同的官能团，每个官能团的含量均符合要求。该反应、纯化以及确定表面修饰水平的实验条件简便，使得该策略成为目前制备具有多样表面化学性质的AuNPs方法的一个有吸引力的替代方案。
