Zhou Shengfang, Zhang Yingli, Wei Zhiwen, Park Sunghoon
The Key Laboratory of Biotechnology for Medicinal Plant of Jiangsu Province, School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Bioresour Technol. 2023 Jun;377:128973. doi: 10.1016/j.biortech.2023.128973. Epub 2023 Mar 25.
Bio-based C3 and C4 bi-functional chemicals are useful monomers in biopolymer production. This review describes recent progresses in the biosynthesis of four such monomers as a hydroxy-carboxylic acid (3-hydroxypropionic acid), a dicarboxylic acid (succinic acid), and two diols (1,3-propanediol and 1,4-butanediol). The use of cheap carbon sources and the development of strains and processes for better product titer, rate and yield are presented. Challenges and future perspectives for (more) economical commercial production of these chemicals are also briefly discussed.
基于生物的C3和C4双功能化学品是生物聚合物生产中有用的单体。本综述描述了四种此类单体生物合成的最新进展，这四种单体分别是一种羟基羧酸（3-羟基丙酸）、一种二羧酸（琥珀酸）和两种二醇（1,3-丙二醇和1,4-丁二醇）。介绍了廉价碳源的使用以及为提高产品滴度、速率和产量而开发的菌株和工艺。还简要讨论了这些化学品（更）经济的商业生产面临的挑战和未来前景。
