Madej J A, Houszka M, Peryt A
Instytut Chorób Zakaźnych i Inwazyjnych AR, Wrocławiu.
Pol Arch Weter. 1987;24(4):559-70.
The authors carried out morphological evaluation of a long-term action of toxic substances at low concentrations (about 1 NDS), contained in raw coke oven gas, i.e. gases: CO, H2S, SO2, NH3 and benzene, as well as dusts containing: C, SiO2, Pb and Cd on the liver and kidneys of three-month old male rats of the Wistar strain. The animals were exposed to the above toxic substances in an experimental chamber for 24 hr, and for 8 hr every day during 12 and 18 months. It was found that pathogenic action of the substances contained in raw coke oven gas was not the total action of all chemical components, but their complicated resultant. Significant differences in the intensity of morphological changes in lungs were observed between rats exposed for 8 hr ans 24 hr/day, in favour of the former. Such a relationship was not observed between 12 and 18 month exposition. Besides the catarrh of the air passages and cellular-fibrous changes in pulmonary alveoli, focal metaplasia of cells of bronchial epithelium was observed, which suggested the possibility of carcinogenic action of coke oven gases and dusts. No distinct morphological differences were found in the liver and kidneys between 8 and 24 hr exposition, whereas great differences were found between 12 and 18 months exposition. Chronic interstitial pyelitis was observed in kidneys after 18 month exposition.
作者对原焦炉煤气（即含有一氧化碳、硫化氢、二氧化硫、氨和苯等气体，以及含有碳、二氧化硅、铅和镉的粉尘）中低浓度（约1 NDS）有毒物质对3个月大的雄性Wistar品系大鼠肝脏和肾脏的长期作用进行了形态学评估。将动物置于实验舱中，使其接触上述有毒物质24小时，并在12个月和18个月期间每天接触8小时。结果发现，原焦炉煤气中所含物质的致病作用并非所有化学成分的综合作用，而是其复杂的综合结果。在每天暴露8小时和24小时的大鼠之间，观察到肺部形态学变化强度存在显著差异，前者更为明显。在暴露12个月和18个月之间未观察到这种关系。除了气道卡他和肺泡细胞纤维性变化外，还观察到支气管上皮细胞灶性化生，这提示焦炉煤气和粉尘可能具有致癌作用。在暴露8小时和24小时的大鼠肝脏和肾脏之间未发现明显的形态学差异，而在暴露12个月和18个月之间则发现了很大差异。暴露18个月后，在肾脏中观察到慢性间质性肾盂炎。
