Wzorek França Dos Santos Isabella, Sauruk da Silva Karien, Regis Bueno Laryssa, Suzane Schneider Vanessa, Silva Schiebel Carolina, Mulinari Turin de Oliveira Natalia, Cristine Malaquias da Silva Liziane, Soares Fernandes Elizabeth, Biondaro Gois Marcelo, Mach Cortes Cordeiro Lucimara, Maria-Ferreira Daniele
Faculdades Pequeno Príncipe, Curitiba, Brazil.
Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil.
Nutr Cancer. 2023;75(5):1382-1398. doi: 10.1080/01635581.2023.2191382. Epub 2023 Mar 27.
Gastrointestinal toxicity, including diarrhea and inflammation, is commonly observed with the use of 5-fluorouracil (5-FU). Several studies have shown that polysaccharides are interesting bioactive macromolecules for the treatment or prevention of gastrointestinal diseases. Therefore, in this study, the effect of a polysaccharide fraction from a mixture of two Guavira species ( and ), referred to here as CPW, on the development of intestinal mucositis was investigated. Intestinal mucositis was induced by a single injection of 5-FU (450 mg/kg), and various doses of CPW (3-100 mg/kg) were tested. CPW attenuated disease development and prevented small bowel dysmotility and colon shortening. CPW prevented the increase in villi width, crypt depth, and mucosal thickness in the duodenum, but not in the colon. Preservation of mucus, reduction of oxidative stress, inflammation, and prevention of the 5-FU-induced enlargement and swelling of the spleen were observed. In conclusion, this study demonstrated for the first time that CPW alleviates the intestinal damage induced by 5-FU and could be used as an adjuvant strategy during chemotherapy.
胃肠道毒性，包括腹泻和炎症，在使用5-氟尿嘧啶（5-FU）时很常见。多项研究表明，多糖是用于治疗或预防胃肠道疾病的有趣生物活性大分子。因此，在本研究中，研究了来自两种番樱桃属植物（和）混合物的多糖组分（本文称为CPW）对肠道粘膜炎发展的影响。通过单次注射5-FU（450mg/kg）诱导肠道粘膜炎，并测试了不同剂量的CPW（3-100mg/kg）。CPW减轻了疾病发展，预防了小肠运动障碍和结肠缩短。CPW阻止了十二指肠绒毛宽度、隐窝深度和粘膜厚度的增加，但对结肠没有作用。观察到粘液的保留、氧化应激和炎症的减轻以及5-FU诱导的脾脏肿大和肿胀的预防。总之，本研究首次证明CPW减轻了5-FU诱导的肠道损伤，并可作为化疗期间的辅助策略。
