Jiang T, Hu Y, Cao J
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); National Health Commission Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2023 Feb 23;35(1):92-97. doi: 10.16250/j.32.1374.2022118.
Liver sinusoidal endothelial cells (LSECs) locate on the surface of hepatic sinusoids. As the first line of defense between the liver and blood, LSECs are the most abundant non-parenchymal cells in the liver. Under physiological conditions, LSECs may induce liver immune tolerance through participating in substance transport and metabolic waste removal, thereby maintaining liver homeostasis, and under pathological conditions, LSECs may promote liver immune response via antigen presentation. LSECs have been found to play a crucial regulatory role in maintaining the balance between liver regeneration and liver fibrosis. This article reviews the progress of researches on LSECs functions, LSECs changes in liver injury, signal pathways associated with regulation of LSECs functions, and the interaction between LSECs and other types of cells in the liver, aiming to elucidate the function of LSECs and their roles in liver diseases.
肝窦内皮细胞（LSECs）位于肝血窦表面。作为肝脏与血液之间的第一道防线，LSECs是肝脏中最丰富的非实质细胞。在生理条件下，LSECs可通过参与物质运输和代谢废物清除来诱导肝脏免疫耐受，从而维持肝脏稳态；而在病理条件下，LSECs可通过抗原呈递促进肝脏免疫反应。研究发现，LSECs在维持肝脏再生与肝纤维化之间的平衡中发挥着关键的调节作用。本文综述了LSECs功能的研究进展、肝损伤时LSECs的变化、与LSECs功能调节相关的信号通路，以及LSECs与肝脏中其他类型细胞之间的相互作用，旨在阐明LSECs的功能及其在肝脏疾病中的作用。
