Bessler H, Sirota L, Weissman Z, Dulitzky F, Djaldetti M
Biol Neonate. 1986;49(2):61-5. doi: 10.1159/000242511.
Platelet count and thrombopoietic activity were investigated in newborns and in infants during their first 4 months of life. Four-day-old newborns, although not thrombocytopenic, showed a significantly reduced platelet count as compared to that of control adults. Furthermore, a significantly lower thrombopoietic activity was found in the sera of newborns compared to that in the sera of adults. In addition, the thrombopoiesis-stimulating factor (TSF) activity in cord serum was significantly lower than that in the mothers' sera. Since 7 of 37 newborns examined in the present study showed a very low TSF activity, lower than that found in the saline controls, the possibility that an inhibitor for thrombopoiesis exists in the newborns is suggested and discussed. The follow-up study revealed a low TSF activity in the sera of 1-month-old infants followed by a gradually increased activity, reaching in the 4th month levels similar to those of adults. Concomitantly with the rise in TSF activity in the serum, an increased platelet count was observed.
对新生儿及出生后4个月内的婴儿的血小板计数和血小板生成活性进行了研究。4日龄的新生儿虽然没有血小板减少，但与对照成人相比，血小板计数显著降低。此外，与成人血清相比，新生儿血清中的血小板生成活性显著降低。另外，脐血血清中的血小板生成刺激因子（TSF）活性明显低于母亲血清中的活性。由于本研究中检测的37名新生儿中有7名显示出非常低的TSF活性，低于生理盐水对照组，因此提示并讨论了新生儿中存在血小板生成抑制剂的可能性。随访研究显示，1月龄婴儿血清中的TSF活性较低，随后活性逐渐增加，在第4个月达到与成人相似的水平。随着血清中TSF活性的升高，观察到血小板计数增加。
