Snapper J R, Bernard G R, Brigham K L
Bull Eur Physiopathol Respir. 1986 Jan-Feb;22(1):257s-260s.
Endotoxemia is used as a model of the adult respiratory distress syndrome in chronically instrumented awake sheep. The toxic effects of endotoxin may be mediated through inflammatory cells and the release of toxic oxidants. N-acetylcysteine (NAC) inhibits the in vivo effects of endotoxemia in chronically instrumented unanesthetized sheep. NAC also functions as a free radical scavenger in vitro. It is possible that the protective effects of pretreatment with NAC result from NAC's ability in vivo to protect against local oxidant injury.
内毒素血症被用作长期植入仪器的清醒绵羊的成人呼吸窘迫综合征模型。内毒素的毒性作用可能通过炎症细胞和毒性氧化剂的释放来介导。N-乙酰半胱氨酸（NAC）可抑制长期植入仪器的未麻醉绵羊体内内毒素血症的作用。NAC在体外也具有自由基清除剂的功能。NAC预处理的保护作用可能源于其在体内防止局部氧化剂损伤的能力。
