Alqarni Mohammed H, Foudah Ahmed I, Aodah Alhussain H, Alkholifi Faisal K, Salkini Mohammad Ayman, Alam Aftab
Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al kharj 11942, Saudi Arabia.
Gels. 2023 Mar 3;9(3):193. doi: 10.3390/gels9030193.
Novel antibiotics are needed due to the rise of antibiotic-resistant pathogens. Traditional antibiotics are ineffective due to antibiotic-resistant microorganisms, and finding alternative therapies is expensive. Hence, plant-derived caraway (Carum carvi) essential oils and antibacterial compounds have been selected as alternatives. In this, caraway essential oil as an antibacterial treatment was investigated using a nanoemulsion gel. Using the emulsification technique, a nanoemulsion gel was developed and characterized in terms of particle size, polydispersity index, pH, and viscosity. The results showed that the nanoemulsion had a mean particle size of 137 nm and an encapsulation efficiency of 92%. Afterward, the nanoemulsion gel was incorporated into the carbopol gel and was found to be transparent and uniform. The gel had in vitro cell viability and antibacterial activity against () and (). The gel safely delivered a transdermal drug with a cell survival rate of over 90%. With a minimal inhibitor concentration (MIC) of 0.78 mg/mL and 0.78 mg/mL, respectively, the gel demonstrated substantial inhibition for and . Lastly, the study demonstrated that caraway essential oil nanoemulsion gels can be efficient in treating and , laying the groundwork for the use of caraway essential oil as an alternative to synthetic antibiotics in the treatment of bacterial infections.
由于抗生素耐药性病原体的增加，新型抗生素是必要的。由于抗生素耐药微生物的存在，传统抗生素无效，而寻找替代疗法成本高昂。因此，植物来源的香菜（Carum carvi）精油和抗菌化合物被选为替代品。在此，使用纳米乳液凝胶研究了香菜精油作为抗菌治疗剂的情况。采用乳化技术制备了纳米乳液凝胶，并对其粒径、多分散指数、pH值和粘度进行了表征。结果表明，该纳米乳液的平均粒径为137nm，包封率为92%。随后，将纳米乳液凝胶加入卡波姆凝胶中，发现其透明且均匀。该凝胶对（）和（）具有体外细胞活力和抗菌活性。该凝胶安全地递送了一种透皮药物，细胞存活率超过90%。该凝胶对（）和（）的最低抑菌浓度（MIC）分别为0.78mg/mL和0.78mg/mL，表现出显著的抑制作用。最后，该研究表明香菜精油纳米乳液凝胶在治疗（）和（）方面可能有效，为香菜精油作为合成抗生素的替代品用于治疗细菌感染奠定了基础。
