Azam Faizul, Alqarni Mohammed H, Alnasser Sulaiman Mohammed, Alam Prawez, Jawaid Talha, Kamal Mehnaz, Khan Shamshir, Alam Aftab
Department of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Unaizah 51911, Saudi Arabia.
Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Gels. 2023 Jan 28;9(2):111. doi: 10.3390/gels9020111.
Over the past decade, researchers have made several efforts to develop gel-based formulations that provide an alternative to traditional hydrogels and emulgel. Due to its excellent antibacterial properties, anise, the main constituent of L., widely used in pharmaceuticals, was selected as the active ingredient in this study. Since many bacteria have developed considerable antibiotic resistance, this research aimed to develop an herbal emulgel for treating skin infections caused by bacteria. Given these obstacles, we developed and evaluated a new, cost-effective topical emulgel solution containing anise essential oil against (). Anise-based emulgels, potential drug delivery platforms, have been evaluated for various parameters, including physical properties, viscosity, pH, rheology, encapsulation efficiency, and in vitro release research. The AEOs emulgel demonstrated remarkable colloidal stability, with a zeta potential of 29 mV, a size of 149.05 nm, and considerable polydispersity. The efficacy of anise-loaded emulgels as antibacterial formulations was evaluated in vitro. was used as a model microbial organism for the antibacterial study. Human keratinocytes (HaCaT) were used to examine the biocompatibility of the emulgel. Molecular docking revealed that the essential oil components of L. possess a high affinity for the bacterial adhesin protein FimH of . These findings indicate that the developed AEOs have the potential to be analyzed using as a model organism.
在过去十年中，研究人员做出了多项努力来开发基于凝胶的制剂，以替代传统水凝胶和乳胶凝胶。由于其出色的抗菌特性，作为L.主要成分的茴芹被广泛用于制药领域，在本研究中被选为活性成分。鉴于许多细菌已产生相当程度的抗生素耐药性，本研究旨在开发一种用于治疗由细菌引起的皮肤感染的草药乳胶凝胶。鉴于这些障碍，我们开发并评估了一种新型、经济高效的含茴芹精油的局部乳胶凝胶溶液，用于对抗（）。基于茴芹的乳胶凝胶作为潜在的药物递送平台，已针对各种参数进行了评估，包括物理性质、粘度、pH值、流变学、包封效率和体外释放研究。茴芹精油乳胶凝胶表现出显著的胶体稳定性，其zeta电位为29 mV（毫伏），粒径为149.05纳米，且具有相当程度的多分散性。体外评估了负载茴芹的乳胶凝胶作为抗菌制剂的功效。（）被用作抗菌研究的模型微生物。使用人角质形成细胞（HaCaT）来检测乳胶凝胶的生物相容性。分子对接显示，L.的精油成分对（）的细菌粘附蛋白FimH具有高亲和力。这些发现表明，所开发的茴芹精油有潜力以（）作为模型生物进行分析。
