Kaliaraj Gobi Saravanan, Shanmugam Dilip Kumar, Dasan Arish, Mosas Kamalan Kirubaharan Amirtharaj
Centre for Nanoscience and Nanotechnology, Sathyabama Institute of Science and Technology, Chennai 600 119, India.
FunGlass-Centre for Functional and Surface Functionalised Glass, Alexander Dubcek University of Trencin, 91150 Trencin, Slovakia.
Gels. 2023 Mar 22;9(3):260. doi: 10.3390/gels9030260.
Hydrogels are a promising material for a variety of applications after appropriate functional and structural design, which alters the physicochemical properties and cell signaling pathways of the hydrogels. Over the past few decades, considerable scientific research has made breakthroughs in a variety of applications such as pharmaceuticals, biotechnology, agriculture, biosensors, bioseparation, defense, and cosmetics. In the present review, different classifications of hydrogels and their limitations have been discussed. In addition, techniques involved in improving the physical, mechanical, and biological properties of hydrogels by admixing various organic and inorganic materials are explored. Future 3D printing technology will substantially advance the ability to pattern molecules, cells, and organs. With significant potential for producing living tissue structures or organs, hydrogels can successfully print mammalian cells and retain their functionalities. Furthermore, recent advances in functional hydrogels such as photo- and pH-responsive hydrogels and drug-delivery hydrogels are discussed in detail for biomedical applications.
经过适当的功能和结构设计后,水凝胶是一种在各种应用中都很有前景的材料,这种设计会改变水凝胶的物理化学性质和细胞信号通路。在过去几十年里,大量科学研究在药物、生物技术、农业、生物传感器、生物分离、国防和化妆品等各种应用中取得了突破。在本综述中,讨论了水凝胶的不同分类及其局限性。此外,还探讨了通过混合各种有机和无机材料来改善水凝胶物理、机械和生物学性质所涉及的技术。未来的3D打印技术将极大地提升对分子、细胞和器官进行图案化的能力。水凝胶在制造活组织结构或器官方面具有巨大潜力,能够成功打印哺乳动物细胞并保留其功能。此外,还详细讨论了功能性水凝胶(如光响应和pH响应水凝胶以及药物递送水凝胶)在生物医学应用方面的最新进展。