静脉噬菌体作为单独疗法治疗复发性耐药性尿路感染的治疗潜力。
Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections.
机构信息
Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0003723. doi: 10.1128/aac.00037-23. Epub 2023 Mar 28.
Abstract
Recurrent urinary tract infections (rUTI) are common in kidney transplant recipients (KTR) and are associated with multidrug resistance and increased morbidity/mortality. Novel antibiotic alternatives to reduce UTI recurrence are critically needed. We describe a case of rUTI due to extended spectrum beta lactamase (ESBL) Klebsiella pneumoniae in a KTR that was treated successfully with 4 weeks of adjunctive intravenous bacteriophage therapy alone, without concomitant antibiotics, and with no recurrence in a year of follow-up.
摘要
复发性尿路感染（rUTI）在肾移植受者（KTR）中很常见，与多药耐药和增加的发病率/死亡率有关。迫切需要新型抗生素替代物来减少 UTI 复发。我们描述了一例 KTR 中由产超广谱β内酰胺酶（ESBL）肺炎克雷伯菌引起的 rUTI，该患者单独接受了 4 周的辅助静脉噬菌体治疗，无需同时使用抗生素，并且在 1 年的随访中没有复发。
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